| Literature DB >> 10817740 |
H Kurokawa1, T Yagi, N Shibata, K Shibayama, K Kamachi, Y Arakawa.
Abstract
A new SHV-derived extended-spectrum beta-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K(m) for CAZ of this enzyme were 7.5 and 30 microM, respectively. SHV-24 was found to have a D179G substitution in the Omega-loop of the enzyme.Entities:
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Year: 2000 PMID: 10817740 PMCID: PMC89944 DOI: 10.1128/AAC.44.6.1725-1727.2000
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191