Literature DB >> 10817733

Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin.

M Peteroy1, A Severin, F Zhao, D Rosner, U Lopatin, H Scherman, A Belanger, B Harvey, G F Hatfull, P J Brennan, N D Connell.   

Abstract

A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.

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Year:  2000        PMID： 10817733      PMCID： PMC89937          DOI： 10.1128/AAC.44.6.1701-1704.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

Review 1.  Genetics and mechanisms of glycopeptide resistance in enterococci.

Authors:  M Arthur; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

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Authors:  E Gallori; R Fani
Journal:  Microbiologica       Date:  1983-01

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Authors:  B Granier; C Duez; S Lepage; S Englebert; J Dusart; O Dideberg; J Van Beeumen; J M Frère; J M Ghuysen
Journal:  Biochem J       Date:  1992-03-15       Impact factor: 3.857

4.  The biochemical mechanisms of resistance by streptococci to the antibiotics D-cycloserine and O-carbamyl-D-serine.

Authors:  R H Reitz; H D Slade; F C Neuhaus
Journal:  Biochemistry       Date:  1967-08       Impact factor: 3.162

5.  Penicillin-binding protein 4 of Escherichia coli: molecular cloning of the dacB gene, controlled overexpression, and alterations in murein composition.

Authors:  B Korat; H Mottl; W Keck
Journal:  Mol Microbiol       Date:  1991-03       Impact factor: 3.501

6.  Direct determination of the properties of peptide transport systems in Escherichia coli, using a fluorescent-labeling procedure.

Authors:  J W Payne; G Bell
Journal:  J Bacteriol       Date:  1979-01       Impact factor: 3.490

7.  Resistance to D-cycloserine in the tubercle bacilli: mutation rate and transport of alanine in parental cells and drug-resistant mutants.

Authors:  H L David
Journal:  Appl Microbiol       Date:  1971-05

Review 8.  Tuberculosis: commentary on a reemergent killer.

Authors:  B R Bloom; C J Murray
Journal:  Science       Date:  1992-08-21       Impact factor: 47.728

9.  Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci.

Authors:  M Arthur; C Molinas; T D Bugg; G D Wright; C T Walsh; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1992-04       Impact factor: 5.191

10.  Conjugal transfer of chromosomal DNA in Mycobacterium smegmatis.

Authors:  L M Parsons; C S Jankowski; K M Derbyshire
Journal:  Mol Microbiol       Date:  1998-05       Impact factor: 3.501
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  6 in total

Review 1.  Resistance to antibiotics targeted to the bacterial cell wall.

Authors:  I Nikolaidis; S Favini-Stabile; A Dessen
Journal:  Protein Sci       Date:  2014-01-17       Impact factor: 6.725

2.  Mycobacterium smegmatis D-Alanine Racemase Mutants Are Not Dependent on D-Alanine for Growth.

Authors:  Ofelia Chacon; Zhengyu Feng; N Beth Harris; Nancy E Cáceres; L Garry Adams; Raúl G Barletta
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

3.  Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine.

Authors:  Zhengyu Feng; Raúl G Barletta
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

4.  Alterations in phospholipid catabolism in Mycobacterium tuberculosis lysX mutant.

Authors:  Erin Maloney; Shichun Lun; Dorota Stankowska; Haidan Guo; Malini Rajagoapalan; William R Bishai; Murty V Madiraju
Journal:  Front Microbiol       Date:  2011-02-11       Impact factor: 5.640

5.  Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis.

Authors:  Erkin Kuru; Atanas Radkov; Xin Meng; Alexander Egan; Laura Alvarez; Amanda Dowson; Garrett Booher; Eefjan Breukink; David I Roper; Felipe Cava; Waldemar Vollmer; Yves Brun; Michael S VanNieuwenhze
Journal:  ACS Chem Biol       Date:  2019-12-05       Impact factor: 5.100

6.  A point mutation in cycA partially contributes to the D-cycloserine resistance trait of Mycobacterium bovis BCG vaccine strains.

Authors:  Jeffrey M Chen; Swapna Uplekar; Stephen V Gordon; Stewart T Cole
Journal:  PLoS One       Date:  2012-08-17       Impact factor: 3.240
  6 in total

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