Literature DB >> 1503450

Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci.

M Arthur1, C Molinas, T D Bugg, G D Wright, C T Walsh, P Courvalin.   

Abstract

The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogenase and therefore appears to be a substrate of VanA in vivo.

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Year:  1992        PMID： 1503450      PMCID： PMC189469          DOI： 10.1128/AAC.36.4.867

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  The VANA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes.

Authors:  S Dutka-Malen; C Molinas; M Arthur; P Courvalin
Journal:  Mol Gen Genet       Date:  1990-12

Review 2.  Antibacterial activities and modes of action of vancomycin and related glycopeptides.

Authors:  R Nagarajan
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

Review 3.  Enzymes in the D-alanine branch of bacterial cell wall peptidoglycan assembly.

Authors:  C T Walsh
Journal:  J Biol Chem       Date:  1989-02-15       Impact factor: 5.157

4.  Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases.

Authors:  M Arthur; C Molinas; S Dutka-Malen; P Courvalin
Journal:  Gene       Date:  1991-07-15       Impact factor: 3.688

5.  Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium.

Authors:  R Leclercq; E Derlot; J Duval; P Courvalin
Journal:  N Engl J Med       Date:  1988-07-21       Impact factor: 91.245

6.  Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.

Authors:  T D Bugg; G D Wright; S Dutka-Malen; M Arthur; P Courvalin; C T Walsh
Journal:  Biochemistry       Date:  1991-10-29       Impact factor: 3.162

7.  Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymogenes.

Authors:  A E Jacob; S J Hobbs
Journal:  J Bacteriol       Date:  1974-02       Impact factor: 3.490

8.  FRUCTOSE-1,6-DIPHOSPHATE REQUIREMENT OF STREPTOCOCCAL LACTIC DEHYDROGENASES.

Authors:  M J WOLIN
Journal:  Science       Date:  1964-11-06       Impact factor: 47.728

9.  Modifications of the acyl-D-alanyl-D-alanine terminus affecting complex-formation with vancomycin.

Authors:  M Nieto; H R Perkins
Journal:  Biochem J       Date:  1971-08       Impact factor: 3.857

10.  Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity.

Authors:  T D Bugg; S Dutka-Malen; M Arthur; P Courvalin; C T Walsh
Journal:  Biochemistry       Date:  1991-02-26       Impact factor: 3.162
  10 in total
  44 in total

Review 1.  Modes and modulations of antibiotic resistance gene expression.

Authors:  Florence Depardieu; Isabelle Podglajen; Roland Leclercq; Ekkehard Collatz; Patrice Courvalin
Journal:  Clin Microbiol Rev       Date:  2007-01       Impact factor: 26.132

Review 2.  Current perspectives on glycopeptide resistance.

Authors:  N Woodford; A P Johnson; D Morrison; D C Speller
Journal:  Clin Microbiol Rev       Date:  1995-10       Impact factor: 26.132

3.  Induction signals for vancomycin resistance encoded by the vanA gene cluster in Enterococcus faecium.

Authors:  M H Lai; D R Kirsch
Journal:  Antimicrob Agents Chemother       Date:  1996-07       Impact factor: 5.191

Review 4.  Diversity among multidrug-resistant enterococci.

Authors:  B E Murray
Journal:  Emerg Infect Dis       Date:  1998 Jan-Mar       Impact factor: 6.883

5.  Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis.

Authors:  Djalal Meziane-Cherif; Frederick A Saul; Ahmed Haouz; Patrice Courvalin
Journal:  J Biol Chem       Date:  2012-09-11       Impact factor: 5.157

6.  Glycopeptide sulfation evades resistance.

Authors:  Lindsay Kalan; Julie Perry; Kalinka Koteva; Maulik Thaker; Gerard Wright
Journal:  J Bacteriol       Date:  2012-10-26       Impact factor: 3.490

7.  Synergy and resistance to synergy between beta-lactam antibiotics and glycopeptides against glycopeptide-resistant strains of Enterococcus faecium.

Authors:  L Gutmann; S al-Obeid; D Billot-Klein; M L Guerrier; E Collatz
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

8.  DdlN from vancomycin-producing Amycolatopsis orientalis C329.2 is a VanA homologue with D-alanyl-D-lactate ligase activity.

Authors:  C G Marshall; G D Wright
Journal:  J Bacteriol       Date:  1998-11       Impact factor: 3.490

9.  The cytoplasmic peptidoglycan precursor of vancomycin-resistant Enterococcus faecalis terminates in lactate.

Authors:  S Handwerger; M J Pucci; K J Volk; J Liu; M S Lee
Journal:  J Bacteriol       Date:  1992-09       Impact factor: 3.490

10.  Proteomic characterization of vanA-containing Enterococcus recovered from Seagulls at the Berlengas Natural Reserve, W Portugal.

Authors:  Hajer Radhouani; Patrícia Poeta; Luís Pinto; Júlio Miranda; Céline Coelho; Carlos Carvalho; Jorge Rodrigues; María López; Carmen Torres; Rui Vitorino; Pedro Domingues; Gilberto Igrejas
Journal:  Proteome Sci       Date:  2010-09-21       Impact factor: 2.480
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