| Literature DB >> 10814391 |
W Luo1, J G Muller, E M Rachlin, C J Burrows.
Abstract
[reaction: see text] Further oxidation of the common DNA lesion 8-oxo-7,8-dihydroguanosine by one-electron oxidants such as IrCl6(2-), Fe(CN)6(3-), or SO4-* leads to two major products, depending upon reaction conditions. In nucleosides at pH 7, 22 degrees C, the principal product is shown herein to be a spiroiminodihydantoin nucleoside, as a diastereomeric mixture, that can be characterized by NMR, ESI-MS/MS, and independent synthesis.Entities:
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Year: 2000 PMID： 10814391 DOI： 10.1021/ol9913643
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005