OBJECTIVE: To examine whether tic severity, comorbid disorders, or both are associated with illness morbidity in youths with Tourette's disorder (TD). METHOD: Subjects were 156 consecutively referred youths (aged 5-20 years) who met DSM-III-R criteria for Tourette's disorder at a major academic medical center. All subjects were evaluated with a clinical interview by a child and adolescent psychiatrist and an assessment battery that included the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Epidemiologic version. Statistical analysis used chi 2 and multivariate logistic regression. RESULTS: Nineteen (12%) of the 156 youths with TD required psychiatric hospitalization. Current age, TD severity, TD duration, obsessive-compulsive disorder, psychosis, major depression, bipolar disorder, panic disorder, and overanxious disorder were significant univariate predictors of psychiatric hospitalization (p < .01). While tic severity was marginally significant as a predictor of psychiatric hospitalization (p < .05), major depression (p < .016) and bipolar disorder (p < .001) were robust predictors of psychiatric hospitalization, even after statistical adjustment for collinearity and correction for all other variables assessed. CONCLUSION: The findings indicate that comorbid mood disorders are strongly associated with illness morbidity in youths with TD, highlighting the importance of attention to comorbidity in patients with TD.
OBJECTIVE: To examine whether tic severity, comorbid disorders, or both are associated with illness morbidity in youths with Tourette's disorder (TD). METHOD: Subjects were 156 consecutively referred youths (aged 5-20 years) who met DSM-III-R criteria for Tourette's disorder at a major academic medical center. All subjects were evaluated with a clinical interview by a child and adolescent psychiatrist and an assessment battery that included the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Epidemiologic version. Statistical analysis used chi 2 and multivariate logistic regression. RESULTS: Nineteen (12%) of the 156 youths with TD required psychiatric hospitalization. Current age, TD severity, TD duration, obsessive-compulsive disorder, psychosis, major depression, bipolar disorder, panic disorder, and overanxious disorder were significant univariate predictors of psychiatric hospitalization (p < .01). While tic severity was marginally significant as a predictor of psychiatric hospitalization (p < .05), major depression (p < .016) and bipolar disorder (p < .001) were robust predictors of psychiatric hospitalization, even after statistical adjustment for collinearity and correction for all other variables assessed. CONCLUSION: The findings indicate that comorbid mood disorders are strongly associated with illness morbidity in youths with TD, highlighting the importance of attention to comorbidity in patients with TD.
Authors: Denis G Sukhodolsky; Angeli Landeros-Weisenberger; Lawrence Scahill; James F Leckman; Robert T Schultz Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-11 Impact factor: 8.829
Authors: Daniel A Gorman; Nancy Thompson; Kerstin J Plessen; Mary M Robertson; James F Leckman; Bradley S Peterson Journal: Br J Psychiatry Date: 2010-07 Impact factor: 9.319
Authors: Danielle C Cath; Tammy Hedderly; Andrea G Ludolph; Jeremy S Stern; Tara Murphy; Andreas Hartmann; Virginie Czernecki; Mary May Robertson; Davide Martino; A Munchau; R Rizzo Journal: Eur Child Adolesc Psychiatry Date: 2011-04 Impact factor: 4.785
Authors: Vilma Gabbay; James S Babb; Rachel G Klein; Aviva M Panzer; Yisrael Katz; Carmen M Alonso; Eva Petkova; Jing Wang; Barbara J Coffey Journal: Pediatrics Date: 2012-05-14 Impact factor: 7.124
Authors: Hilde M Huisman-van Dijk; Suzy J M A Matthijssen; Ruben T S Stockmann; Anne V Fritz; Danielle C Cath Journal: Acta Neurol Scand Date: 2019-09-17 Impact factor: 3.209