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Literature DB >> 10801479

So do we understand how enzymes work?

Abstract

Between 1930 and 1975 biochemical and structural analysis of enzymes led to a clear set of ideas that might form a basis for detailed understanding of enzyme action. Further development required energetic and thermodynamic analysis of enzymes in an aqueous medium, beyond the computational power then available. Structural enzymology advanced in other directions, but the fundamental questions of enzyme action must soon be re-opened.

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Year: 2000 PMID： 10801479 DOI： 10.1016/s0969-2126(00)00125-8

Source DB: PubMed Journal: Structure ISSN： 0969-2126 Impact factor: 5.006

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Cited

18 in total

1. From proteases to proteomics.

Authors: H Neurath
Journal: Protein Sci Date: 2001-04 Impact factor: 6.725

2. How important are entropic contributions to enzyme catalysis?

Authors: J Villa; M Strajbl; T M Glennon; Y Y Sham; Z T Chu; A Warshel
Journal: Proc Natl Acad Sci U S A Date: 2000-10-24 Impact factor: 11.205

3. Scaffolding Catalysis: Expanding the Repertoire of Bifunctional Catalysts.

Authors: Kian L Tan; Xixi Sun; Amanda D Worthy
Journal: Synlett Date: 2012-02-01 Impact factor: 2.454

4. Nickel(II) chelatase variants directly evolved from murine ferrochelatase: porphyrin distortion and kinetic mechanism.

Authors: Neil R McIntyre; Ricardo Franco; John A Shelnutt; Gloria C Ferreira
Journal: Biochemistry Date: 2011-02-10 Impact factor: 3.162

Review 9. Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymes.

Authors: Daniel Herschlag; Aditya Natarajan
Journal: Biochemistry Date: 2013-03-14 Impact factor: 3.162

Review 10. Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis.

Authors: Sinisa Urban
Journal: Biochem J Date: 2010-01-15 Impact factor: 3.857

So do we understand how enzymes work?

1. From proteases to proteomics.

2. How important are entropic contributions to enzyme catalysis?

3. Scaffolding Catalysis: Expanding the Repertoire of Bifunctional Catalysts.

4. Nickel(II) chelatase variants directly evolved from murine ferrochelatase: porphyrin distortion and kinetic mechanism.

5. Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase.

Review 6. Electric Fields and Enzyme Catalysis.

7. Protein Crystallography from the Perspective of Technology Developments.

8. Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.

Review 9. Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymes.

Review 10. Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis.