| Literature DB >> 10801476 |
V L Healy1, I A Lessard, D I Roper, J R Knox, C T Walsh.
Abstract
Vancomycin binds to bacterial cell-wall intermediates to achieve its antibiotic effect. Infections of vancomycin-resistant enterococci are, however, becoming an increasing problem; the bacteria are resistant because they synthesize different cell-wall intermediates. The enzymes involved in cell-wall biosynthesis, therefore, are potential targets for combating this resistance. Recent biochemical and crystallographic results are providing mechanistic and structural details about some of these targets.Entities:
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Year: 2000 PMID： 10801476 DOI： 10.1016/s1074-5521(00)00116-2
Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521