Literature DB >> 10800593

Phosphotriesterase: an enzyme in search of its natural substrate.

F M Raushel1, H M Holden.   

Abstract

The bacterial PTE is able to catalyze the hydrolysis of a wide range of organophosphate nerve agents. The active site has been shown to consist of a unique binuclear metal center that has evolved to deliver hydroxide to the site of bond cleavage. The reaction rate for the hydrolysis of activated substrates such as paraoxon is limited by product release or an associated protein conformational change.

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Year:  2000        PMID： 10800593     DOI： 10.1002/9780470123201.ch2

Source DB:  PubMed          Journal:  Adv Enzymol Relat Areas Mol Biol        ISSN： 0065-258X


  16 in total

1.  Directed evolution of an extremely fast phosphotriesterase by in vitro compartmentalization.

Authors:  Andrew D Griffiths; Dan S Tawfik
Journal:  EMBO J       Date:  2003-01-02       Impact factor: 11.598

2.  Characterization of the catalytic activity of U2 and U6 snRNAs.

Authors:  Saba Valadkhan; James L Manley
Journal:  RNA       Date:  2003-07       Impact factor: 4.942

Review 3.  Toward a systems biology perspective on enzyme evolution.

Authors:  Shelley D Copley
Journal:  J Biol Chem       Date:  2011-11-08       Impact factor: 5.157

4.  Conformational variability of organophosphorus hydrolase upon soman and paraoxon binding.

Authors:  Diego E B Gomes; Roberto D Lins; Pedro G Pascutti; Chenghong Lei; Thereza A Soares
Journal:  J Phys Chem B       Date:  2011-12-05       Impact factor: 2.991

5.  Molecular dynamics simulations of the detoxification of paraoxon catalyzed by phosphotriesterase.

Authors:  Xin Zhang; Ruibo Wu; Lingchun Song; Yuchun Lin; Menghai Lin; Zexing Cao; Wei Wu; Yirong Mo
Journal:  J Comput Chem       Date:  2009-11-30       Impact factor: 3.376

6.  Structure of diethyl phosphate bound to the binuclear metal center of phosphotriesterase.

Authors:  Jungwook Kim; Ping-Chuan Tsai; Shi-Lu Chen; Fahmi Himo; Steven C Almo; Frank M Raushel
Journal:  Biochemistry       Date:  2008-08-15       Impact factor: 3.162

7.  Comparative investigation of the reaction mechanisms of the organophosphate-degrading phosphotriesterases from Agrobacterium radiobacter (OpdA) and Pseudomonas diminuta (OPH).

Authors:  Marcelo M Pedroso; Fernanda Ely; Nataša Mitić; Margaret C Carpenter; Lawrence R Gahan; Dean E Wilcox; James L Larrabee; David L Ollis; Gerhard Schenk
Journal:  J Biol Inorg Chem       Date:  2014-08-08       Impact factor: 3.358

8.  Contribution of the active-site metal cation to the catalytic activity and to the conformational stability of phosphotriesterase: temperature- and pH-dependence.

Authors:  Daniel Rochu; Nathalie Viguié; Frédérique Renault; David Crouzier; Marie-Thérèse Froment; Patrick Masson
Journal:  Biochem J       Date:  2004-06-15       Impact factor: 3.857

9.  Purification, substrate range, and metal center of AtzC: the N-isopropylammelide aminohydrolase involved in bacterial atrazine metabolism.

Authors:  Nir Shapir; Jeffrey P Osborne; Gilbert Johnson; Michael J Sadowsky; Lawrence P Wackett
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490

10.  Visualizing the Dynamic Metalation State of New Delhi Metallo-β-lactamase-1 in Bacteria Using a Reversible Fluorescent Probe.

Authors:  Radhika Mehta; Dann D Rivera; David J Reilley; Dominique Tan; Pei W Thomas; Abigail Hinojosa; Alesha C Stewart; Zishuo Cheng; Caitlyn A Thomas; Michael W Crowder; Anastassia N Alexandrova; Walter Fast; Emily L Que
Journal:  J Am Chem Soc       Date:  2021-05-26       Impact factor: 16.383
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