Literature DB >> 10788609

Solitary HERV-K LTRs possess bi-directional promoter activity and contain a negative regulatory element in the U5 region.

A N Domansky1, E P Kopantzev, E V Snezhkov, Y B Lebedev, C Leib-Mosch, E D Sverdlov.   

Abstract

Reporter gene analysis of HERV-K solitary long terminal repeats (LTRs) showed that they retain detectable activity in human teratocarcinoma cells, and can direct the transcription in both orientations relative to the reporter gene. Deletion analysis demonstrated the possible existence of alternative promoters within the LTR as well as a silencer-like element in the U5 region. Our results indicate also that all-trans-retinoic acid is capable of modulating expression of the reporter gene directed by a HERV-K LTR in NT2/D1 cells.

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Year:  2000        PMID： 10788609     DOI： 10.1016/s0014-5793(00)01460-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  42 in total

1.  Detection of retroviral antisense transcripts and promoter activity of the HERV-K(C4) insertion in the MHC class III region.

Authors:  Michaela Mack; Klaus Bender; Peter M Schneider
Journal:  Immunogenetics       Date:  2004-08-12       Impact factor: 2.846

2.  Large-scale determination of the methylation status of retrotransposons in different tissues using a methylation tags approach.

Authors:  Konstantin Khodosevich; Yuri Lebedev; Eugene D Sverdlov
Journal:  Nucleic Acids Res       Date:  2004-02-18       Impact factor: 16.971

3.  Transcriptional activation by bidirectional RNA polymerase II elongation over a silent promoter.

Authors:  Olivier Leupin; Catia Attanasio; Samuel Marguerat; Myriam Tapernoux; Stylianos E Antonarakis; Bernard Conrad
Journal:  EMBO Rep       Date:  2005-10       Impact factor: 8.807

4.  Large-scale survey of cytosine methylation of retrotransposons and the impact of readout transcription from long terminal repeats on expression of adjacent rice genes.

Authors:  Khalil Kashkush; Vadim Khasdan
Journal:  Genetics       Date:  2007-12       Impact factor: 4.562

Review 5.  Retroelements and their impact on genome evolution and functioning.

Authors:  Elena Gogvadze; Anton Buzdin
Journal:  Cell Mol Life Sci       Date:  2009-08-02       Impact factor: 9.261

6.  Comprehensive analysis of human endogenous retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray.

Authors:  Wolfgang Seifarth; Oliver Frank; Udo Zeilfelder; Birgit Spiess; Alex D Greenwood; Rüdiger Hehlmann; Christine Leib-Mösch
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

7.  Sequence analysis of porcine endogenous retrovirus long terminal repeats and identification of transcriptional regulatory regions.

Authors:  Carolyn A Wilson; Sabahat Laeeq; Armin Ritzhaupt; Winston Colon-Moran; Fayth K Yoshimura
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

Review 8.  Implication of the HTLV-I bZIP factor gene in the leukemogenesis of adult T-cell leukemia.

Authors:  Yorifumi Satou; Masao Matsuoka
Journal:  Int J Hematol       Date:  2007-08       Impact factor: 2.490

9.  The IDDM-associated solitary retroviral promoters DQ-LTR3 and DQ-LTR13 have a distinct impact on the expression of selected DQB1 genes in different cell lines in vitro.

Authors:  Katrin Krach; Klaus Badenhoop; Ralf R Tönjes
Journal:  Immunogenetics       Date:  2003-10-18       Impact factor: 2.846

10.  Evolutionary conservation of orthoretroviral long terminal repeats (LTRs) and ab initio detection of single LTRs in genomic data.

Authors:  Farid Benachenhou; Patric Jern; Merja Oja; Göran Sperber; Vidar Blikstad; Panu Somervuo; Samuel Kaski; Jonas Blomberg
Journal:  PLoS One       Date:  2009-04-13       Impact factor: 3.240
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