Literature DB >> 107854

Conversion of 2,4,6-trinitrophenol to a mutagen by Pseudomonas aeruginosa.

J F Wyman, H E Guard, W D Won, J H Quay.   

Abstract

A strain of Pseudomonas aeruginosa reduced 2,4,6-trinitrophenol (picric acid) to 2-amino-4,6-dinitrophenol (picramic acid) under anaerobic conditions. Mutagenic assays of picric acid and picramic acid were carried out with histidine-requiring strains of Salmonella typhimurium. Picric acid (10 micrograms per plate) demonstrated mutagenicity (both frame shift and base substitution-gype mutations) only after activation with a rat liver homogenate preparation. Picramic acid (1 microgram per plate) induced both base pair substitution and frame shift-tupe mutations without activation by the rat liver preparation.

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Year:  1979        PMID： 107854      PMCID： PMC243191          DOI： 10.1128/aem.37.2.222-226.1979

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  7 in total

1.  Pyocyanine biosynthesis by Pseudomonas aeruginosa.

Authors:  N GROSSOWICZ; P HAYAT; Y S HALPERN
Journal:  J Gen Microbiol       Date:  1957-06

2.  Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.

Authors:  J McCann; N E Spingarn; J Kobori; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205

3.  An improved bacterial test system for the detection and classification of mutagens and carcinogens.

Authors:  B N Ames; F D Lee; W E Durston
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

4.  Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.

Authors:  W D Won; L H DiSalvo; J Ng
Journal:  Appl Environ Microbiol       Date:  1976-04       Impact factor: 4.792

5.  Metabolic disposition of 2,4,6-trinitrotoluene.

Authors:  W D Won; R J Heckly; D J Glover; J C Hoffsommer
Journal:  Appl Microbiol       Date:  1974-03

6.  Mutagenicity of cycasin aglycone (methylazoxymethanol), a naturally occurring carcinogen.

Authors:  D W Smith
Journal:  Science       Date:  1966-05-27       Impact factor: 47.728

7.  Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.

Authors:  B N Ames; W E Durston; E Yamasaki; F D Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205
  7 in total
  3 in total

1.  Environmental chemistry of 1,2-propanediol dinitrate: azeotrope formation, photolysis and biodegradability.

Authors:  J F Wyman; H E Guard; W M Coleman
Journal:  Arch Environ Contam Toxicol       Date:  1984-11       Impact factor: 2.804

2.  Mineralization of 2,4,6-trinitrophenol (picric acid): characterization and phylogenetic identification of microbial strains.

Authors:  J Rajan; K Valli; R E Perkins; F S Sariaslani; S M Barns; A L Reysenbach; S Rehm; M Ehringer; N R Pace
Journal:  J Ind Microbiol       Date:  1996-05

3.  Initial hydrogenation during catabolism of picric acid by Rhodococcus erythropolis HL 24-2.

Authors:  H Lenke; H J Knackmuss
Journal:  Appl Environ Microbiol       Date:  1992-09       Impact factor: 4.792
  3 in total

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