Literature DB >> 10784451

Control of homeostasis of CD8+ memory T cells by opposing cytokines.

C C Ku1, M Murakami, A Sakamoto, J Kappler, P Marrack.   

Abstract

Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.

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Year:  2000        PMID： 10784451     DOI： 10.1126/science.288.5466.675

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  241 in total

1.  IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients.

Authors:  N Azimi; M Nagai; S Jacobson; T A Waldmann
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

2.  IL-7 is critical for homeostatic proliferation and survival of naive T cells.

Authors:  J T Tan; E Dudl; E LeRoy; R Murray; J Sprent; K I Weinberg; C D Surh
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-10       Impact factor: 11.205

3.  IL-15-induced conversion of monocytes to mature dendritic cells.

Authors:  K U Saikh; A S Khan; T Kissner; R G Ulrich
Journal:  Clin Exp Immunol       Date:  2001-12       Impact factor: 4.330

4.  Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments.

Authors:  Qing Ge; Hui Hu; Herman N Eisen; Jianzhu Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-05       Impact factor: 11.205

Review 5.  Naive and memory B cells in T-cell-dependent and T-independent responses.

Authors:  R H Zubler
Journal:  Springer Semin Immunopathol       Date:  2001-12

6.  Homeostatic T cell proliferation in a T cell-dendritic cell coculture system.

Authors:  Qing Ge; Deborah Palliser; Herman N Eisen; Jianzhu Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-19       Impact factor: 11.205

7.  Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes.

Authors:  N Manjunath; P Shankar; J Wan; W Weninger; M A Crowley; K Hieshima; T A Springer; X Fan; H Shen; J Lieberman; U H von Andrian
Journal:  J Clin Invest       Date:  2001-09       Impact factor: 14.808

8.  Measuring the diaspora for virus-specific CD8+ T cells.

Authors:  D R Marshall; S J Turner; G T Belz; S Wingo; S Andreansky; M Y Sangster; J M Riberdy; T Liu; M Tan; P C Doherty
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-08       Impact factor: 11.205

9.  Addition of an IL-15 mutant/FCgamma2A antagonist protein protects islet allografts from rejection overriding costimulation blockade.

Authors:  S Ferrari-Lacraz; X X Zheng; Y S Kim; W Maslinski; T B Strom
Journal:  Transplant Proc       Date:  2002-05       Impact factor: 1.066

Review 10.  Qualitative differences between naïve and memory T cells.

Authors:  Marion Berard; David F Tough
Journal:  Immunology       Date:  2002-06       Impact factor: 7.397
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