M E Gurney1, A G Tomasselli, R L Heinrikson. Show Affiliations » 1. Protein Sciences, Pharmacia Corp., 301 Henrietta Street, Kalamazoo, MI USA. mark.e.gurney@am.pnu.com
Abstract
Mesh: See more » Amino Acid Chloromethyl Ketones/pharmacologyAmino Acid Chloromethyl Ketones/therapeutic useAmyotrophic Lateral Sclerosis/drug therapyAmyotrophic Lateral Sclerosis/enzymologyAmyotrophic Lateral Sclerosis/pathologyAnimalsApoptosis/drug effectsCaspase 1/metabolismCaspase 3Caspase InhibitorsCaspases/metabolismCysteine Proteinase Inhibitors/pharmacologyCysteine Proteinase Inhibitors/therapeutic useDisease Models, AnimalHumansInterleukin-1/metabolismMiceMice, TransgenicMotor Neurons/drug effectsMotor Neurons/pathologyNeuroprotective Agents/pharmacologyNeuroprotective Agents/therapeutic useSpinal Cord/drug effectsSpinal Cord/enzymologySpinal Cord/pathologySuperoxide Dismutase/geneticsSuperoxide Dismutase/metabolismSuperoxide Dismutase-1
Substances: See more » Amino Acid Chloromethyl KetonesCaspase InhibitorsCysteine Proteinase InhibitorsInterleukin-1Neuroprotective AgentsSOD1 protein, humanbenzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneSod1 protein, mouseSuperoxide DismutaseSuperoxide Dismutase-1CASP3 protein, humanCasp3 protein, mouseCaspase 3CaspasesCaspase 1
Year: 2000 PMID: 10777410 DOI: 10.1126/science.288.5464.283
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728