Literature DB >> 10767576

Age-dependent changes in B lymphocyte development in man and mouse.

P Ghia1, F Melchers, A G Rolink.   

Abstract

In recent years, detailed analyses of B cell development in both humans and mice have revealed similar subsets of precursors along the same pathway of differentiation. From these studies it also became clear that both species undergo age related changes in this B lymphocyte development program. In this review we summarize these findings and discuss, potential mechanisms underlying these age related changes, and possible causative correlations between these changes and age related B cell abnormalities.

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Year:  2000        PMID： 10767576     DOI： 10.1016/s0531-5565(99)00095-9

Source DB:  PubMed          Journal:  Exp Gerontol        ISSN： 0531-5565            Impact factor:   4.032


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