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Literature DB >> 10766734

Ro ribonucleoproteins contribute to the resistance of Deinococcus radiodurans to ultraviolet irradiation.

Abstract

The genome of the radiation-resistant eubacterium Deinococcus radiodurans contains an ortholog of an RNA-binding protein known as the Ro 60-kD autoantigen. This protein, which was previously identified only in higher eukaryotes, is normally bound to small RNAs known as Y RNAs. We show that the Ro protein ortholog Rsr contributes to the resistance of D. radiodurans to UV irradiation. Rsr binds several small RNAs, encoded upstream of rsr, that accumulate following UV irradiation. One of these RNAs resembles a Y RNA. These results suggest that Ro RNPs could similarly contribute to the recovery of higher cells following UV irradiation.

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Year: 2000 PMID： 10766734 PMCID： PMC316496

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

31 in total

1. Antibody penetration into the cells of mice and men.

Authors: D P McCauliffe
Journal: J Invest Dermatol Date: 1996-07 Impact factor: 8.551

2. A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors.

Authors: C A O'Brien; S L Wolin
Journal: Genes Dev Date: 1994-12-01 Impact factor: 11.361

3. A misfolded form of 5S rRNA is complexed with the Ro and La autoantigens.

Authors: H Shi; C A O'Brien; D J Van Horn; S L Wolin
Journal: RNA Date: 1996-08 Impact factor: 4.942

4. La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth.

Authors: C J Yoo; S L Wolin
Journal: Mol Cell Biol Date: 1994-08 Impact factor: 4.272

Review 5. Life with 6000 genes.

Authors: A Goffeau; B G Barrell; H Bussey; R W Davis; B Dujon; H Feldmann; F Galibert; J D Hoheisel; C Jacq; M Johnston; E J Louis; H W Mewes; Y Murakami; P Philippsen; H Tettelin; S G Oliver
Journal: Science Date: 1996-10-25 Impact factor: 47.728

6. In vivo damage and recA-dependent repair of plasmid and chromosomal DNA in the radiation-resistant bacterium Deinococcus radiodurans.

Authors: M J Daly; L Ouyang; P Fuchs; K W Minton
Journal: J Bacteriol Date: 1994-06 Impact factor: 3.490

Review 7. Autoantibodies in the diagnosis of systemic rheumatic diseases.

Authors: C A von Mühlen; E M Tan
Journal: Semin Arthritis Rheum Date: 1995-04 Impact factor: 5.532

8. Novel ionizing radiation-sensitive mutants of Deinococcus radiodurans.

Authors: K S Udupa; P A O'Cain; V Mattimore; J R Battista
Journal: J Bacteriol Date: 1994-12 Impact factor: 3.490

9. Caenorhabditis elegans embryos contain only one major species of Ro RNP.

Authors: D J Van Horn; D Eisenberg; C A O'Brien; S L Wolin
Journal: RNA Date: 1995-05 Impact factor: 4.942

10. A perinucleolar compartment contains several RNA polymerase III transcripts as well as the polypyrimidine tract-binding protein, hnRNP I.

Authors: A G Matera; M R Frey; K Margelot; S L Wolin
Journal: J Cell Biol Date: 1995-06 Impact factor: 10.539

47 in total

Ro ribonucleoproteins contribute to the resistance of Deinococcus radiodurans to ultraviolet irradiation.

1. Antibody penetration into the cells of mice and men.

2. A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors.

3. A misfolded form of 5S rRNA is complexed with the Ro and La autoantigens.

4. La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth.

Review 5. Life with 6000 genes.

6. In vivo damage and recA-dependent repair of plasmid and chromosomal DNA in the radiation-resistant bacterium Deinococcus radiodurans.

Review 7. Autoantibodies in the diagnosis of systemic rheumatic diseases.

8. Novel ionizing radiation-sensitive mutants of Deinococcus radiodurans.

9. Caenorhabditis elegans embryos contain only one major species of Ro RNP.

10. A perinucleolar compartment contains several RNA polymerase III transcripts as well as the polypyrimidine tract-binding protein, hnRNP I.

1. Comparative genomics and evolution of proteins involved in RNA metabolism.

2. A computational approach to identify genes for functional RNAs in genomic sequences.

3. New technology may reveal mechanisms of radiation resistance in Deinococcus radiodurans.

4. A role for a bacterial ortholog of the Ro autoantigen in starvation-induced rRNA degradation.

5. Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis.

6. Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity.

7. RNA chaperone activity of protein components of human Ro RNPs.

8. Functional requirement of noncoding Y RNAs for human chromosomal DNA replication.

Review 9. Sjögren's syndrome--study of autoantigens and autoantibodies.

10. Packaging of host mY RNAs by murine leukemia virus may occur early in Y RNA biogenesis.