Literature DB >> 8849441

Life with 6000 genes.

A Goffeau1, B G Barrell, H Bussey, R W Davis, B Dujon, H Feldmann, F Galibert, J D Hoheisel, C Jacq, M Johnston, E J Louis, H W Mewes, Y Murakami, P Philippsen, H Tettelin, S G Oliver.   

Abstract

The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.

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Year:  1996        PMID： 8849441     DOI： 10.1126/science.274.5287.546

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  1023 in total

1.  A sampling of the yeast proteome.

Authors:  B Futcher; G I Latter; P Monardo; C S McLaughlin; J I Garrels
Journal:  Mol Cell Biol       Date:  1999-11       Impact factor: 4.272

2.  YPD, PombePD and WormPD: model organism volumes of the BioKnowledge library, an integrated resource for protein information.

Authors:  M C Costanzo; M E Crawford; J E Hirschman; J E Kranz; P Olsen; L S Robertson; M S Skrzypek; B R Braun; K L Hopkins; P Kondu; C Lengieza; J E Lew-Smith; M Tillberg; J I Garrels
Journal:  Nucleic Acids Res       Date:  2001-01-01       Impact factor: 16.971

3.  Networking proteins in yeast.

Authors:  T R Hazbun; S Fields
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

4.  Complex mtDNA constitutes an approximate 620-kb insertion on Arabidopsis thaliana chromosome 2: implication of potential sequencing errors caused by large-unit repeats.

Authors:  R M Stupar; J W Lilly; C D Town; Z Cheng; S Kaul; C R Buell; J Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-17       Impact factor: 11.205

5.  GenEST, a powerful bidirectional link between cDNA sequence data and gene expression profiles generated by cDNA-AFLP.

Authors:  L Qin; P Prins; J T Jones; H Popeijus; G Smant; J Bakker; J Helder
Journal:  Nucleic Acids Res       Date:  2001-04-01       Impact factor: 16.971

6.  Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology.

Authors:  T M Hackeng; J H Griffin; P E Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

7.  A Holliday junction resolvase from Pyrococcus furiosus: functional similarity to Escherichia coli RuvC provides evidence for conserved mechanism of homologous recombination in Bacteria, Eukarya, and Archaea.

Authors:  K Komori; S Sakae; H Shinagawa; K Morikawa; Y Ishino
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

8.  A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis.

Authors:  M Couture; S R Yeh; B A Wittenberg; J B Wittenberg; Y Ouellet; D L Rousseau; M Guertin
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

9.  A phylogenomic study of DNA repair genes, proteins, and processes.

Authors:  J A Eisen; P C Hanawalt
Journal:  Mutat Res       Date:  1999-12-07       Impact factor: 2.433

Review 10.  Higher levels of organization in the interphase nucleus of cycling and differentiated cells.

Authors:  A R Leitch
Journal:  Microbiol Mol Biol Rev       Date:  2000-03       Impact factor: 11.056
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