Literature DB >> 10762166

Synphilin-1 is present in Lewy bodies in Parkinson's disease.

K Wakabayashi1, S Engelender, M Yoshimoto, S Tsuji, C A Ross, H Takahashi.   

Abstract

Alpha-synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the alpha-synuclein gene are responsible for familial forms of PD and alpha-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with alpha-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.

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Year:  2000        PMID： 10762166

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  63 in total

1.  Synphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease.

Authors:  Kunikazu Tanji; Fumiaki Mori; Katsumi Kito; Akiyoshi Kakita; Junsei Mimura; Ken Itoh; Hitoshi Takahashi; Tetsu Kamitani; Koichi Wakabayashi
Journal:  J Neuropathol Exp Neurol       Date:  2011-10       Impact factor: 3.685

Review 2.  Rare genetic mutations shed light on the pathogenesis of Parkinson disease.

Authors:  Ted M Dawson; Valina L Dawson
Journal:  J Clin Invest       Date:  2003-01       Impact factor: 14.808

Review 3.  The Lewy body in Parkinson's disease and related neurodegenerative disorders.

Authors:  Koichi Wakabayashi; Kunikazu Tanji; Saori Odagiri; Yasuo Miki; Fumiaki Mori; Hitoshi Takahashi
Journal:  Mol Neurobiol       Date:  2012-05-24       Impact factor: 5.590

Review 4.  Drug targets from genetics: α-synuclein.

Authors:  Karin M Danzer; Pamela J McLean
Journal:  CNS Neurol Disord Drug Targets       Date:  2011-09-01       Impact factor: 4.388

5.  Genome-wide DNA methylation profiling of peripheral blood mononuclear cells in irritable bowel syndrome.

Authors:  S Mahurkar; C Polytarchou; D Iliopoulos; C Pothoulakis; E A Mayer; L Chang
Journal:  Neurogastroenterol Motil       Date:  2015-12-16       Impact factor: 3.598

6.  Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson's disease.

Authors:  T Franck; R Krueger; D Woitalla; T Müller; S Engelender; O Riess
Journal:  J Neural Transm (Vienna)       Date:  2006-06-06       Impact factor: 3.575

7.  NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1.

Authors:  Kunikazu Tanji; Tomoaki Tanaka; Fumiaki Mori; Katsumi Kito; Hitoshi Takahashi; Koichi Wakabayashi; Tetsu Kamitani
Journal:  Am J Pathol       Date:  2006-08       Impact factor: 4.307

Review 8.  Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson's disease.

Authors:  Sandeep K Sharma; Smriti Priya
Journal:  Cell Mol Life Sci       Date:  2016-08-13       Impact factor: 9.261

9.  Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.

Authors:  Anne-Maria Poehler; Wei Xiang; Philipp Spitzer; Verena Elisabeth Luise May; Holger Meixner; Edward Rockenstein; Oldriska Chutna; Tiago Fleming Outeiro; Juergen Winkler; Eliezer Masliah; Jochen Klucken
Journal:  Autophagy       Date:  2014       Impact factor: 16.016

10.  TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies.

Authors:  Kunikazu Tanji; Tetsu Kamitani; Fumiaki Mori; Akiyoshi Kakita; Hitoshi Takahashi; Koichi Wakabayashi
Journal:  Neurobiol Dis       Date:  2010-01-18       Impact factor: 5.996
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