| Literature DB >> 10762037 |
K Dodo1, M Takahashi, Y Yamada, Y Sugimoto, Y Hashimoto, R Shirai.
Abstract
We have developed a novel class of cdc25A inhibitors by drastic modification of the hydrophobic and hydrophilic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC50 = 7.7 microM) and caused GI arrest of HL60 cells.Entities:
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Year: 2000 PMID： 10762037 DOI： 10.1016/s0960-894x(00)00065-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823