Literature DB >> 10761985

Effect of long-term feeding with acetyl-L-carnitine on the age-related changes in rat brain lipid composition: a study by 31P NMR spectroscopy.

T Aureli1, M E Di Cocco, G Capuani, R Ricciolini, C Manetti, A Miccheli, F Conti.   

Abstract

Changes in brain lipid composition have been determined in 24 months-old Fischer rats with respect to 6 months-old ones. The cerebral levels of sphingomyelin and cholesterol were found to be significantly increased in aged rats, whereas the amount of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, and phosphatidic acid appear to be unaffected by aging. Long-term feeding with acetyl-L-carnitine was able to reduce the age-dependent increase of both sphingomyelin and cholesterol cerebral levels with no effect on the other measured phospholipids. These findings shown that changes in membrane lipid metabolism and/or composition represent one of the alterations occurring in rat brain with aging, and that long-term feeding with acetyl-L-carnitine can be useful in normalizing these age-dependent disturbances.

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Year:  2000        PMID： 10761985     DOI： 10.1023/a:1007501306623

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  34 in total

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2.  The phospholipid composition of erythrocyte ghosts and plasma lipoproteins in diabetes type 1 in children.

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3.  Effect of acetyl-L-carnitine on recovery of brain phosphorus metabolites and lactic acid level during reperfusion after cerebral ischemia in the rat--study by 13P- and 1H-NMR spectroscopy.

Authors:  T Aureli; A Miccheli; M E Di Cocco; O Ghirardi; A Giuliani; M T Ramacci; F Conti
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4.  The effect of aging and acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria.

Authors:  G Paradies; F M Ruggiero; M N Gadaleta; E Quagliariello
Journal:  Biochim Biophys Acta       Date:  1992-01-31

5.  Distribution of dolichol and dolichyl phosphate in human brain.

Authors:  M Andersson; E L Appelkvist; K Kristensson; G Dallner
Journal:  J Neurochem       Date:  1987-09       Impact factor: 5.372

6.  Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity.

Authors:  T M Hagen; R T Ingersoll; C M Wehr; J Lykkesfeldt; V Vinarsky; J C Bartholomew; M H Song; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-04       Impact factor: 11.205

7.  Lipid compositions of different regions of the human brain during aging.

Authors:  M Söderberg; C Edlund; K Kristensson; G Dallner
Journal:  J Neurochem       Date:  1990-02       Impact factor: 5.372

8.  Dexamethasone-dependent modulation of cholesterol levels in human lymphoblastoid B cell line through sphingosine production.

Authors:  A Miccheli; A Tomassini; R Ricciolini; M E Di Cocco; E Piccolella; C Manetti; F Conti
Journal:  Biochim Biophys Acta       Date:  1994-03-31

Review 9.  Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport.

Authors:  C F Roff; E Goldin; M E Comly; A Cooney; A Brown; M T Vanier; S P Miller; R O Brady; P G Pentchev
Journal:  Dev Neurosci       Date:  1991       Impact factor: 2.984

10.  Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts.

Authors:  J P Slotte; E L Bierman
Journal:  Biochem J       Date:  1988-03-15       Impact factor: 3.857
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  7 in total

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2.  Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery.

Authors:  S P Patel; P G Sullivan; T S Lyttle; D S K Magnuson; A G Rabchevsky
Journal:  Neuroscience       Date:  2012-03-15       Impact factor: 3.590

3.  Aging induces tissue-specific changes in cholesterol metabolism in rat brain and liver.

Authors:  Kosara Smiljanic; Tim Vanmierlo; Aleksandra Mladenovic Djordjevic; Milka Perovic; Natasa Loncarevic-Vasiljkovic; Vesna Tesic; Ljubisav Rakic; Sabera Ruzdijic; Dieter Lutjohann; Selma Kanazir
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4.  A solid-state NMR study of phospholipid-cholesterol interactions: sphingomyelin-cholesterol binary systems.

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5.  Ageing-induced alterations in lipid/phospholipid profiles of rat brain and liver mitochondria: implications for mitochondrial energy-linked functions.

Authors:  Hiren R Modi; Surendra S Katyare; Minal A Patel
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Review 6.  Mechanisms underlying the anti-wasting effect of L-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies.

Authors:  Robert Ringseis; Janine Keller; Klaus Eder
Journal:  Eur J Nutr       Date:  2013-03-19       Impact factor: 5.614

7.  Cholesterol metabolism in aging simultaneously altered in liver and nervous system.

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  7 in total

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