Literature DB >> 1543717

The effect of aging and acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria.

G Paradies1, F M Ruggiero, M N Gadaleta, E Quagliariello.   

Abstract

The effect of aging and treatment with acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria was studied. It was found that the activity of the phosphate carrier was reduced by aging. Treatment of aged rats with acetyl-L-carnitine reversed this effect. The mitochondrial level of cardiolipin was decreased with aging. Treatment of aged rats with acetyl-L-carnitine restored the level of cardiolipin to that of young rats. It is proposed that acetyl-L-carnitine may restore the correct phospholipid composition (cardiolipin level) of the mitochondrial membrane, altered by aging, thereby restoring the activity of the phosphate carrier.

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Year:  1992        PMID： 1543717     DOI： 10.1016/0005-2736(92)90103-s

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  35 in total

Review 1.  Sarcolemmal dependence of cardiac protection and stress-resistance: roles in aged or diseased hearts.

Authors:  Louise E See Hoe; Lauren T May; John P Headrick; Jason N Peart
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2.  Acetyl-L-carnitine increases mitochondrial protein acetylation in the aged rat heart.

Authors:  Janos Kerner; Elizabeth Yohannes; Kwangwon Lee; Ashraf Virmani; Aleardo Koverech; Claudio Cavazza; Mark R Chance; Charles Hoppel
Journal:  Mech Ageing Dev       Date:  2015-02-07       Impact factor: 5.432

3.  An improved method for separating cardiolipin by HPLC.

Authors:  Gwendolyn Barceló-Coblijn; Eric J Murphy
Journal:  Lipids       Date:  2008-07-18       Impact factor: 1.880

Review 4.  Recent advances in metabolic imaging.

Authors:  Robert J Gropler
Journal:  J Nucl Cardiol       Date:  2013-12       Impact factor: 5.952

5.  N-Acetylsphingosine stimulates phosphatidylglycerolphosphate synthase activity in H9c2 cardiac cells.

Authors:  F Y Xu; S L Kelly; G M Hatch
Journal:  Biochem J       Date:  1999-02-01       Impact factor: 3.857

6.  Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery.

Authors:  S P Patel; P G Sullivan; T S Lyttle; D S K Magnuson; A G Rabchevsky
Journal:  Neuroscience       Date:  2012-03-15       Impact factor: 3.590

7.  Cardiolipin remodeling in a Chinese hamster lung fibroblast cell line deficient in oxidative energy production.

Authors:  A Rusnak; R Mangat; F Xu; G McClarty; G M Hatch
Journal:  J Bioenerg Biomembr       Date:  1997-06       Impact factor: 2.945

8.  Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity.

Authors:  T M Hagen; R T Ingersoll; C M Wehr; J Lykkesfeldt; V Vinarsky; J C Bartholomew; M H Song; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-04       Impact factor: 11.205

9.  Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress.

Authors:  Jung H Suh; Shi-Hua Heath; Tory M Hagen
Journal:  Free Radic Biol Med       Date:  2003-11-01       Impact factor: 7.376

10.  Effects of various dietary fats on cardiolipin acyl composition during ontogeny of mice.

Authors:  A Berger; M E Gershwin; J B German
Journal:  Lipids       Date:  1992-08       Impact factor: 1.880
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