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Literature DB >> 10761983

The Na+-Ca2+ exchange inhibitor KB-R7943 inhibits high K+-induced increases in intracellular Ca2+ concentration and [3H]noradrenaline release in the human neuroblastoma SH-SY5Y.

H Nakamura¹, Y Kawasaki, N Arakawa, M Saeki, S Maeda, Y Koyama, A Baba, T Matsuda.

Abstract

The effects of the Na+-Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943) on depolarization-induced Ca2+ signal and [3H]noradrenaline release were examined in SH-SY5Y cells. KB-R7943 at 10 microM significantly inhibited high K+-induced increase in intracellular Ca2+ concentration. KB-R7943 also inhibited high K+-evoked release of [3H]noradrenaline from the cells. These findings suggest that the Na+-Ca2+ exchanger in the reverse mode is involved at least partly in depolarization-induced transmitter release.

Entities: Chemical Disease Gene Species

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Year: 2000 PMID： 10761983 DOI： 10.1023/a:1007597105714

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

16 in total

1. Rate of Na+/Ca2+ exchange across the plasma membrane of synaptosomes measured using the fluorescence of chlorotetracycline. Implications to calcium homeostasis in synaptic terminals.

Authors: E García-Martín; C Gutiérrez-Merino
Journal: Biochim Biophys Acta Date: 1996-04-26

2. Involvement of Na+-Ca2+ exchanger in reperfusion-induced delayed cell death of cultured rat astrocytes.

Authors: T Matsuda; K Takuma; E Nishiguchi; H Hashimoto; J Azuma; A Baba
Journal: Eur J Neurosci Date: 1996-05 Impact factor: 3.386

Review 3. Sodium-calcium exchange: recent advances.

Authors: L V Hryshko; K D Philipson
Journal: Basic Res Cardiol Date: 1997 Impact factor: 17.165

4. Role of Ca2+ in metabolic inhibition-induced norepinephrine release in rat brain synaptosomes.

Authors: X J Du; A Bobik; P J Little; M D Esler; A M Dart
Journal: Circ Res Date: 1997-02 Impact factor: 17.367

5. Morphine prevents peroxynitrite-induced death of human neuroblastoma SH-SY5Y cells through a direct scavenging action.

Authors: T Kanesaki; M Saeki; Y Ooi; M Suematsu; K Matsumoto; M Sakuda; K Saito; S Maeda
Journal: Eur J Pharmacol Date: 1999-05-21 Impact factor: 4.432

Review 6. Na(+)-Ca2+ exchanger: physiology and pharmacology.

Authors: T Matsuda; K Takuma; A Baba
Journal: Jpn J Pharmacol Date: 1997-05

7. The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury.

Authors: U H Schröder; J Breder; C F Sabelhaus; K G Reymann
Journal: Neuropharmacology Date: 1999-02 Impact factor: 5.250

The Na+-Ca2+ exchange inhibitor KB-R7943 inhibits high K+-induced increases in intracellular Ca2+ concentration and [3H]noradrenaline release in the human neuroblastoma SH-SY5Y.

1. Rate of Na+/Ca2+ exchange across the plasma membrane of synaptosomes measured using the fluorescence of chlorotetracycline. Implications to calcium homeostasis in synaptic terminals.

2. Involvement of Na+-Ca2+ exchanger in reperfusion-induced delayed cell death of cultured rat astrocytes.

Review 3. Sodium-calcium exchange: recent advances.

4. Role of Ca2+ in metabolic inhibition-induced norepinephrine release in rat brain synaptosomes.

5. Morphine prevents peroxynitrite-induced death of human neuroblastoma SH-SY5Y cells through a direct scavenging action.

Review 6. Na(+)-Ca2+ exchanger: physiology and pharmacology.

7. The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury.

8. Time-resolved changes in intracellular calcium following depolarization of rat brain synaptosomes.

9. Potassium- and carbachol-evoked release of [3H]noradrenaline from human neuroblastoma cells, SH-SY5Y.

10. A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1.

1. A flagellar K(+)-dependent Na(+)/Ca(2+) exchanger keeps Ca(2+) low in sea urchin spermatozoa.

2. Magnesium lithospermate B extracted from Salvia miltiorrhiza elevates intracellular Ca(2+) level in SH-SY5Y cells.