Literature DB >> 10758405

CR3: a general purpose adhesion-recognition receptor essential for innate immunity.

M R Ehlers1.   

Abstract

CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobial defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the CD11b knockout mouse. CR3 is a highly versatile pattern-recognition receptor that activates leukocytes via signaling complexes and actin reorganization, mediates phagocytosis, and promotes leukocyte transmigration.

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Year:  2000        PMID： 10758405     DOI： 10.1016/s1286-4579(00)00299-9

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  100 in total

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Review 7.  The Neuro-Immune-Regulators (NIREGs) Promote Tissue Resilience; a Vital Component of the Host's Defense Strategy against Neuroinflammation.

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8.  Integrin-directed modulation of macrophage responses to biomaterials.

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9.  Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.

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Review 10.  Leukocyte integrins and their ligand interactions.

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