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Literature DB >> 19184539

Leukocyte integrins and their ligand interactions.

Young-Min Hyun¹, Craig T Lefort, Minsoo Kim.

Abstract

Although critical for cell adhesion and migration during normal immune-mediated reactions, leukocyte integrins are also involved in the pathogenesis of diverse clinical conditions including autoimmune diseases and chronic inflammation. Leukocyte integrins therefore have been targets for anti-adhesive therapies to treat the inflammatory disorders. Recently, the therapeutic potential of integrin antagonists has been demonstrated in psoriasis and multiple sclerosis. However, current therapeutics broadly affect integrin functions and, thus, yield unfavorable side effects. This review discusses the major leukocyte integrins and the anti-adhesion strategies for treating immune diseases.

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Year: 2009 PMID： 19184539 PMCID： PMC2990789 DOI： 10.1007/s12026-009-8101-1

Source DB: PubMed Journal: Immunol Res ISSN： 0257-277X Impact factor: 2.829

123 in total

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26 in total

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2. Mary Allen Engle Award: The glue of life--a career retrospective.

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Journal: Trans Am Clin Climatol Assoc Date: 2011

Review 3. Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse.

Authors: Audrey Le Floc'h; Morgan Huse
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4. The direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged.

Authors: George A Dominguez; Nicholas R Anderson; Daniel A Hammer
Journal: Integr Biol (Camb) Date: 2015-02-12 Impact factor: 2.192

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Journal: Clin Exp Immunol Date: 2013-09 Impact factor: 4.330