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Literature DB >> 10758157

RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human.

Abstract

We have cloned a human cDNA that is related to the RNA polymerase I transcription factor Rrn3 of Saccharomyces cerevisiae. The recombinant human protein displays both sequence similarity and immunological crossreactivity to yeast Rrn3 and is capable of rescuing a yeast strain carrying a disruption of the RRN3 gene in vivo. Point mutation of an amino acid that is conserved between the yeast and human proteins compromises the function of each factor, confirming that the observed sequence similarity is functionally significant. Rrn3 is the first RNA polymerase I-specific transcription factor shown to be functionally conserved between yeast and mammals, suggesting that at least one mechanism that regulates ribosomal RNA synthesis is conserved among eukaryotes.

Entities: Gene Species

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Year: 2000 PMID： 10758157 PMCID： PMC18300 DOI： 10.1073/pnas.080063997

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

1. An approach for isolation of mutants defective in 35S ribosomal RNA synthesis in Saccharomyces cerevisiae.

Authors: Y Nogi; L Vu; M Nomura
Journal: Proc Natl Acad Sci U S A Date: 1991-08-15 Impact factor: 11.205

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Authors: P B Mahajan; E A Thompson
Journal: J Biol Chem Date: 1990-09-25 Impact factor: 5.157

3. Hormonal regulation of transcription of rDNA. The role of TFIC in formation of initiation complexes.

Authors: P B Mahajan; P K Gokal; E A Thompson
Journal: J Biol Chem Date: 1990-09-25 Impact factor: 5.157

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Authors: S P Bell; R M Learned; H M Jantzen; R Tjian
Journal: Science Date: 1988-09-02 Impact factor: 47.728

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Authors: E Bateman; M R Paule
Journal: Cell Date: 1986-11-07 Impact factor: 41.582

6. Transcription of mouse rDNA is regulated by an activated subform of RNA polymerase I.

Authors: J Tower; B Sollner-Webb
Journal: Cell Date: 1987-09-11 Impact factor: 41.582

7. Rapid and efficient site-specific mutagenesis without phenotypic selection.

Authors: T A Kunkel
Journal: Proc Natl Acad Sci U S A Date: 1985-01 Impact factor: 11.205

8. Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription.

Authors: J Keener; C A Josaitis; J A Dodd; M Nomura
Journal: J Biol Chem Date: 1998-12-11 Impact factor: 5.157

9. Transcription complex formation at the mouse rDNA promoter involves the stepwise association of four transcription factors and RNA polymerase I.

Authors: A Schnapp; I Grummt
Journal: J Biol Chem Date: 1991-12-25 Impact factor: 5.157

10. A growth-dependent transcription initiation factor (TIF-IA) interacting with RNA polymerase I regulates mouse ribosomal RNA synthesis.

Authors: A Schnapp; C Pfleiderer; H Rosenbauer; I Grummt
Journal: EMBO J Date: 1990-09 Impact factor: 11.598

56 in total

1. TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p.

Authors: J Bodem; G Dobreva; U Hoffmann-Rohrer; S Iben; H Zentgraf; H Delius; M Vingron; I Grummt
Journal: EMBO Rep Date: 2000-08 Impact factor: 8.807

RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human.

1. An approach for isolation of mutants defective in 35S ribosomal RNA synthesis in Saccharomyces cerevisiae.

2. Hormonal regulation of transcription of rDNA. Purification and characterization of the hormone-regulated transcription factor IC.

3. Hormonal regulation of transcription of rDNA. The role of TFIC in formation of initiation complexes.

4. Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis.

5. Regulation of eukaryotic ribosomal RNA transcription by RNA polymerase modification.

6. Transcription of mouse rDNA is regulated by an activated subform of RNA polymerase I.

7. Rapid and efficient site-specific mutagenesis without phenotypic selection.

8. Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription.

9. Transcription complex formation at the mouse rDNA promoter involves the stepwise association of four transcription factors and RNA polymerase I.

10. A growth-dependent transcription initiation factor (TIF-IA) interacting with RNA polymerase I regulates mouse ribosomal RNA synthesis.

1. TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p.

2. The recruitment of RNA polymerase I on rDNA is mediated by the interaction of the A43 subunit with Rrn3.

3. Differential roles of phosphorylation in the formation of transcriptional active RNA polymerase I.

4. New model for the yeast RNA polymerase I transcription cycle.

5. Evolution of eukaryotic transcription: insights from the genome of Giardia lamblia.

6. Nucleolus as an oxidative stress sensor in the yeast Saccharomyces cerevisiae.

7. PAF53 is essential in mammalian cells: CRISPR/Cas9 fails to eliminate PAF53 expression.

8. UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat.

9. Whole-genome sequencing of a laboratory-evolved yeast strain.

10. RPD3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase.