| Literature DB >> 10747399 |
I A Kozlov1, M Zielinski, B Allart, L Kerremans, A Van Aerschot, R Busson, P Herdewijn, L E Orgel.
Abstract
Altritol nucleic acids (ANAs) are RNA analogues with a phosphorylated D-altritol backbone. The nucleobase is attached at the 2-(S)-position of the carbohydrate moiety. We report that ANA oligomers are superior to the corresponding DNA, RNA, and HNA (hexitol nucleic acid) in supporting efficient nonenzymatic template-directed synthesis of complementary RNAs from nucleoside-5'-phosphoro-2-methyl imidazolides. Activated ANA and HNA monomers do not oligomerize efficiently on DNA, RNA, HNA, or ANA templates.Entities:
Keywords: NASA Discipline Exobiology; Non-NASA Center
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Year: 2000 PMID： 10747399 DOI： 10.1002/(sici)1521-3765(20000103)6:1<151::aid-chem151>3.0.co;2-h
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236