| Literature DB >> 10745090 |
G Shiota1, T Kunisada, K Oyama, A Udagawa, T Nomi, K Tanaka, A Tsutsumi, M Isono, T Nakamura, H Hamada, T Sakatani, S Sell, K Sato, H Ito, H Kawasaki.
Abstract
To clarify the effect of hepatocyte growth factor (HGF) on proliferation of hepatic oval cells, we transferred HGF gene into liver of the Solt-Farber rat model. Male Fisher 344 rats were infected with a recombinant adenovirus carrying the cDNA for HGF (pAxCAHGF) from tail vein. HGF mRNA showed its peak at 4 days, and diminished thereafter. The total and proliferating cell nuclear antigen-positive hepatic oval cells were significantly elevated in HGF-transferred rats, in which stem cell factor and c-kit mRNA increased at each time point. Our results suggest that in vivo transfer of the HGF gene into liver accelerates proliferation of hepatic oval cells in the Solt-Farber model in rats.Entities:
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Year: 2000 PMID： 10745090 DOI： 10.1016/s0014-5793(00)01337-5
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124