Literature DB >> 25237624

Bone marrow cell-based regenerative therapy for liver cirrhosis.

Takafumi Saito1, Kyoko Tomita1, Hiroaki Haga1, Kazuo Okumoto1, Yoshiyuki Ueno1.   

Abstract

Bone marrow cells are capable of differentiation into liver cells. Therefore, transplantation of bone marrow cells has considerable potential as a future therapy for regeneration of damaged liver tissue. Autologous bone marrow infusion therapy has been applied to patients with liver cirrhosis, and improvement of liver function parameters has been demonstrated. In this review, we summarize clinical trials of regenerative therapy using bone marrow cells for advanced liver diseases including cirrhosis, as well as topics pertaining to basic in vitro or in vivo approaches in order to outline the essentials of this novel treatment modality.

Entities:  

Keywords:  Bone marrow; Cirrhosis; Liver regeneration; Stem cell; Transplantation

Year:  2013        PMID： 25237624      PMCID： PMC4145572          DOI： 10.5662/wjm.v3.i4.65

Source DB:  PubMed          Journal:  World J Methodol        ISSN： 2222-0682


  47 in total

1.  Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells.

Authors:  I Avital; D Inderbitzin; T Aoki; D B Tyan; A H Cohen; C Ferraresso; J Rozga; W S Arnaout; A A Demetriou
Journal:  Biochem Biophys Res Commun       Date:  2001-10-19       Impact factor: 3.575

2.  Improved conditions to induce hepatocytes from rat bone marrow cells in culture.

Authors:  Masahiro Miyazaki; Ichiro Akiyama; Masakiyo Sakaguchi; Emiko Nakashima; Mayumi Okada; Ken Kataoka; Nam-ho Huh
Journal:  Biochem Biophys Res Commun       Date:  2002-10-18       Impact factor: 3.575

Review 3.  Hepatic stem cells.

Authors:  Stuart Forbes; Pamela Vig; Richard Poulsom; Howard Thomas; Malcolm Alison
Journal:  J Pathol       Date:  2002-07       Impact factor: 7.996

4.  Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes.

Authors:  Liang Peng; Dong-ying Xie; Bing-Liang Lin; Jing Liu; Hai-peng Zhu; Chan Xie; Yu-bao Zheng; Zhi-liang Gao
Journal:  Hepatology       Date:  2011-07-14       Impact factor: 17.425

5.  Enhanced expression of fibroblast growth factor 2 in bone marrow cells and its potential role in the differentiation of hepatic epithelial stem-like cells into the hepatocyte lineage.

Authors:  Hiroaki Haga; Takafumi Saito; Kazuo Okumoto; Satoshi Ugajin; Chikako Sato; Rika Ishii; Yuko Nishise; Junitsu Ito; Hisayoshi Watanabe; Koji Saito; Hitoshi Togashi; Sumio Kawata
Journal:  Cell Tissue Res       Date:  2010-12-09       Impact factor: 5.249

6.  Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes.

Authors:  Tsuyoshi Ishikawa; Shuji Terai; Yohei Urata; Yoshio Marumoto; Koji Aoyama; Isao Sakaida; Tomoaki Murata; Hiroshi Nishina; Koh Shinoda; Shunji Uchimura; Yoshihiko Hamamoto; Kiwamu Okita
Journal:  Cell Tissue Res       Date:  2005-10-14       Impact factor: 5.249

7.  Controlled trials in hepatitis B virus-related decompensate liver cirrhosis: peripheral blood monocyte transplant versus granulocyte-colony-stimulating factor mobilization therapy.

Authors:  Y Han; L Yan; G Han; X Zhou; L Hong; Z Yin; X Zhang; S Wang; J Wang; A Sun; Z Liu; H Xie; K Wu; J Ding; D Fan
Journal:  Cytotherapy       Date:  2008       Impact factor: 5.414

8.  Autologous infusion of expanded mobilized adult bone marrow-derived CD34+ cells into patients with alcoholic liver cirrhosis.

Authors:  Madhava Pai; Dimitris Zacharoulis; Miroslav N Milicevic; Salah Helmy; Long R Jiao; Natasa Levicar; Paul Tait; Michael Scott; Stephen B Marley; Kevin Jestice; Maria Glibetic; Devinder Bansi; Shahid A Khan; Despina Kyriakou; Christos Rountas; Andrew Thillainayagam; Joanna P Nicholls; Steen Jensen; Jane F Apperley; Myrtle Y Gordon; Nagy A Habib
Journal:  Am J Gastroenterol       Date:  2008-07-12       Impact factor: 10.864

9.  Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat.

Authors:  Z Hu; R P Evarts; K Fujio; E R Marsden; S S Thorgeirsson
Journal:  Am J Pathol       Date:  1993-06       Impact factor: 4.307

10.  Stem cell therapy for human liver cirrhosis: a cautious analysis of the results.

Authors:  Stefania Lorenzini; Pietro Andreone
Journal:  Stem Cells       Date:  2007-05-31       Impact factor: 6.277
View more
  4 in total

1.  Autologous mobilized peripheral blood CD34(+) cell infusion in non-viral decompensated liver cirrhosis.

Authors:  Mithun Sharma; Padaki Nagaraja Rao; Mitnala Sasikala; Mamata Reddy Kuncharam; Chimpa Reddy; Vardaraj Gokak; Bpss Raju; Jagdeesh R Singh; Piyal Nag; D Nageshwar Reddy
Journal:  World J Gastroenterol       Date:  2015-06-21       Impact factor: 5.742

Review 2.  Mesenchymal stem cell therapy for cirrhosis: Present and future perspectives.

Authors:  Young Woo Eom; Gaeun Kim; Soon Koo Baik
Journal:  World J Gastroenterol       Date:  2015-09-28       Impact factor: 5.742

3.  Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis.

Authors:  Liting Zhang; Dan Zhou; Junfeng Li; Xiaoming Yan; Jun Zhu; Ping Xiao; Tuo Chen; Xiaodong Xie
Journal:  Med Sci Monit       Date:  2019-09-24

4.  Autologous bone marrow stem cell transplantation via the hepatic artery for the treatment of hepatitis B virus-related cirrhosis: a PRISMA-compliant meta-analysis based on the Chinese population.

Authors:  Ani Sun; Wenni Gao; Ting Xiao
Journal:  Stem Cell Res Ther       Date:  2020-03-05       Impact factor: 6.832
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.