| Literature DB >> 10744057 |
M Mizuguchi1, S Takashima, H Yamanouchi, Y Nakazato, H Mitani, O Hino.
Abstract
The Eker rat is a model for human tuberous sclerosis (TSC) caused by a mutation in the Tsc2 gene. We describe here histological and immunohistochemical findings of the brain lesions in Eker rats, with emphasis on 2 novel lesions found in this study: a cortical tuber and an anaplastic ganglioglioma. The rat cortical tuber resembled those of humans, and further confirmed the value of this animal model as a tool for investigating the molecular pathology of tuberous sclerosis. On the other hand, the rat anaplastic ganglioglioma had features of a malignant neoplasm that are absent from human subependymal giant cell astrocytomas.Entities:
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Year: 2000 PMID： 10744057 DOI： 10.1093/jnen/59.3.188
Source DB: PubMed Journal: J Neuropathol Exp Neurol ISSN： 0022-3069 Impact factor: 3.685