Lowered birth weight among infants born to women with a high intake of fish contaminated with persistent organochlorine compounds.

In Sweden fatty fish from the Baltic Sea (at the Swedish east coast) constitute the main exposure route for persistent organochlorine compounds (POC). The present study assessed reproductive outcomes among fishermen's sisters from the Swedish east coast, who were shown to had had a relatively high consumption of contaminated fish in early life. For relevant comparison, we used a similar cohort from the Swedish west coast, where the contamination of fish is considerable less. The east coast cohort women had an increased risk of having an infant with low birth weight (LBW; <2500 g) as compared with the west coast cohort women (odds ratio (OR) 1.6. 95% confidence interval 1.1-2.3). The results strengthen the hypothesized association between exposure to POC during childhood and adolescence and an increased risk for LBW.