| Literature DB >> 10731151 |
S Faure1, L Meyer, D Costagliola, C Vaneensberghe, E Genin, B Autran, J F Delfraissy, D H McDermott, P M Murphy, P Debré, I Théodorou, C Combadière.
Abstract
Human immunodeficiency virus (HIV) enters cells in vitro via CD4 and a coreceptor. Which of 15 known coreceptors are important in vivo is poorly defined but may be inferred from disease-modifying mutations, as for CCR5. Here two single nucleotide polymorphisms are described in Caucasians in CX3CR1, an HIV coreceptor and leukocyte chemotactic/adhesion receptor for the chemokine fractalkine. HIV-infected patients homozygous for CX3CR1-I249 M280, a variant haplotype affecting two amino acids (isoleucine-249 and methionine-280), progressed to AIDS more rapidly than those with other haplotypes. Functional CX3CR1 analysis showed that fractalkine binding is reduced among patients homozygous for this particular haplotype. Thus, CX3CR1-I249 M280 is a recessive genetic risk factor in HIV/AIDS.Entities:
Mesh：
Substances：
Year: 2000 PMID： 10731151 DOI： 10.1126/science.287.5461.2274
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728