Literature DB >> 10729146

A novel subgenomic murine leukemia virus RNA transcript results from alternative splicing.

J Déjardin1, G Bompard-Maréchal, M Audit, T J Hope, M Sitbon, M Mougel.   

Abstract

Here we show the existence of a novel subgenomic 4.4-kb RNA in cells infected with the prototypic replication-competent Friend or Moloney murine leukemia viruses (MuLV). This RNA derives by splicing from an alternative donor site (SD') within the capsid-coding region to the canonical envelope splice acceptor site. The position and the sequence of SD' was highly conserved among mammalian type C and D oncoviruses. Point mutations used to inactivate SD' without changing the capsid-coding ability affected viral RNA splicing and reduced viral replication in infected cells.

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Year:  2000        PMID： 10729146      PMCID： PMC111880          DOI： 10.1128/jvi.74.8.3709-3714.2000

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

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5.  Use of a focal immunofluorescence assay on live cells for quantitation of retroviruses: distinction of host range classes in virus mixtures and biological cloning of dual-tropic murine leukemia viruses.

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  19 in total

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