Literature DB >> 10728907

Brain derived neurotrophic factor protects human neuroblastoma cells from DNA damaging agents.

D S Middlemas1, B K Kihl, N M Moody.   

Abstract

Neurotrophins are required for survival of neurons during development and may act as survival factors to cells undergoing stress. We tested whether brain derived neurotrophic factor (BDNF) protects neuroblastoma (NB) cells from cytotoxic agents using a model NB cell line, NB 1643, which expresses functional tropomyosin related kinase B (TRKB) following treatment with all-trans-retinoic acid. TRKB is the receptor for BDNF. BDNF increases the EC50 values in survival assays for cisplatin, doxorubicin, and topotecan by two to three fold. Thus, BDNF does indeed protect cells drugs that damage DNA. Cisplatin and doxorubicin are used to treat NB. Topotecan is in clinical studies for the treatment of NB. Since these drugs induce DNA damage, we also investigated whether BDNF might afford protection from gamma irradiation. BDNF also induces more than a two fold resistance to gamma irradiation. Since BDNF protects cells from agents with different mechanisms of damaging DNA and resistance, it seems likely that BDNF may alter a common signaling pathway required for cell death initiation by DNA damaging agents.

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Year:  1999        PMID： 10728907     DOI： 10.1023/a:1006342423175

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  65 in total

1.  Molecular cloning and expression of brain-derived neurotrophic factor.

Authors:  J Leibrock; F Lottspeich; A Hohn; M Hofer; B Hengerer; P Masiakowski; H Thoenen; Y A Barde
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Authors:  I R Radford
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1985-07

3.  Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor.

Authors:  R Yao; G M Cooper
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4.  Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor.

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Authors:  J Frisén; V M Verge; S Cullheim; H Persson; K Fried; D S Middlemas; T Hunter; T Hökfelt; M Risling
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

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Authors:  G M Brodeur; R C Seeger; M Schwab; H E Varmus; J M Bishop
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7.  Insulin-like growth factors act synergistically with basic fibroblast growth factor and nerve growth factor to promote chromaffin cell proliferation.

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Authors:  R J Smeyne; R Klein; A Schnapp; L K Long; S Bryant; A Lewin; S A Lira; M Barbacid
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9.  The insulin-like growth factor I system in the rat cerebellum: developmental regulation and role in neuronal survival and differentiation.

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Journal:  J Neurosci Res       Date:  1994-10-01       Impact factor: 4.164

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Authors:  A Ghosh; J Carnahan; M E Greenberg
Journal:  Science       Date:  1994-03-18       Impact factor: 47.728
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7.  The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.

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10.  A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells.

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