Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation.

Literature DB >> 3874180

The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation.

Abstract

The neutral filter elution technique has been used to examine the relationship between X-ray-induced DNA double-strand breakage (dsb) and lethal lesions. The ratios of the different lesions produced by X-irradiation were varied by irradiation in the presence of different radiomodifiers, and in each case the same linear relationship between lethal lesions and induced DNA dsb was found. This relationship also held for cells given a hyperthermic treatment before irradiation. It is concluded that DNA dsb is probably the lethal lesion induced by ionizing radiation.

Mesh：

Substances：

Year: 1985 PMID： 3874180 DOI： 10.1080/09553008514551051

Source DB: PubMed Journal: Int J Radiat Biol Relat Stud Phys Chem Med ISSN： 0020-7616

Keyword Cloud
Cited

30 in total

1. Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.

Authors: Dana A Löser; Atsushi Shibata; Akiko K Shibata; Lisa J Woodbine; Penny A Jeggo; Anthony J Chalmers
Journal: Mol Cancer Ther Date: 2010-06-08 Impact factor: 6.261

Review 2. The role of repair in radiobiology.

Authors: T Alper; W A Cramp
Journal: Experientia Date: 1989-01-15

10. Radiation sensitivities in various anticancer-drug-resistant human lung cancer cell lines and mechanism of radiation cross-resistance in a cisplatin-resistant cell line.

Authors: F Oshita; Y Fujiwara; N Saijo
Journal: J Cancer Res Clin Oncol Date: 1992 Impact factor: 4.553

The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation.

1. Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.

Review 2. The role of repair in radiobiology.

3. DNA fragmentation by gamma radiation and electron beams using atomic force microscopy.

4. Amino acids and their derivatives as radioprotective agents.

Review 5. Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells.

6. The mTOR inhibitor rapamycin suppresses DNA double-strand break repair.

7. Differential protection of radiation-induced DNA single-strand breaks and cell survival by solcoseryl.

8. Deficiency in DNA repair in mouse lymphoma strain L5178Y-S.

Review 9. Biological consequences of strand breaks in plasmid and viral DNA.

10. Radiation sensitivities in various anticancer-drug-resistant human lung cancer cell lines and mechanism of radiation cross-resistance in a cisplatin-resistant cell line.