Literature DB >> 10726869

Influence of production variables on the sphericity of melt pellets.

P W Heng1, T W Wong, L W Chan.   

Abstract

This paper reports the influence of post-melt impeller speed, post-melt processing time, binder concentration and particle size of bulk material on the sphericity of pellets produced by melt pelletization in a high shear mixer. Lactose was used as the bulk material with polyethylene glycol 3000 as a meltable binder. The sphericity of pellets was found to be affected by post-melt impeller speed and post-melt processing time. Binder concentration and particle size of bulk material had a lesser effect on pellet sphericity. The melt pelletization process can be divided into two spheronization phases (a fast initial rate, followed by a slower rate). The change in the spheronization rate was associated with the pellet size, porosity and flow pattern of the processing material. The present study established a bi-exponential mathematical model to relate the pellet sphericity with post-melt specific energy consumption. The relationship of pellet sphericity with post-melt specific energy consumption was independent of the effects of the production variables.

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Year:  2000        PMID: 10726869     DOI: 10.1248/cpb.48.420

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  3 in total

1.  Optimization of hot melt extrusion parameters for sphericity and hardness of polymeric face-cut pellets.

Authors:  Abdullah S Alshetaili; Bjad K Almutairy; Saad M Alshahrani; Eman A Ashour; Roshan V Tiwari; Sultan M Alshehri; Xin Feng; Bader B Alsulays; Soumyajit Majumdar; Nigel Langley; Karl Kolter; Andreas Gryczke; Scott T Martin; Michael A Repka
Journal:  Drug Dev Ind Pharm       Date:  2016-05-04       Impact factor: 3.225

2.  Functionality of cross-linked polyvinylpyrrolidone as a spheronization aid: a promising alternative to microcrystalline cellulose.

Authors:  Celine V Liew; Li Gu; Josephine L P Soh; Paul W S Heng
Journal:  Pharm Res       Date:  2005-08-03       Impact factor: 4.200

Review 3.  Quality aspects in the development of pelletized dosage forms.

Authors:  Surendra Agrawal; Joneth Fernandes; Fuzail Shaikh; Vishwa Patel
Journal:  Heliyon       Date:  2022-02-15
  3 in total

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