Literature DB >> 10725408

Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach.

J Talon1, M Salvatore, R E O'Neill, Y Nakaya, H Zheng, T Muster, A García-Sastre, P Palese.   

Abstract

We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza A virus possesses anti-IFN activity. We now present evidence that influenza A and B viruses encoding altered viral NS1 proteins are highly attenuated in the mouse host, yet provide protection from challenge with wild-type viruses.

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Year:  2000        PMID： 10725408      PMCID： PMC18238          DOI： 10.1073/pnas.070525997

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

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Journal:  Immunology       Date:  1989-07       Impact factor: 7.397

2.  A universal influenza A vaccine based on the extracellular domain of the M2 protein.

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Journal:  Nat Med       Date:  1999-10       Impact factor: 53.440

3.  Transcriptional and posttranscriptional regulation of exogenous human beta interferon gene in simian cells defective in interferon synthesis.

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Journal:  Mol Cell Biol       Date:  1986-06       Impact factor: 4.272

4.  Isolation and preliminary characterization of a highly cytolytic influenza B virus variant with an aberrant NS gene.

Authors:  T Tanaka; M Urabe; H Goto; K Tobita
Journal:  Virology       Date:  1984-06       Impact factor: 3.616

5.  The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation.

Authors:  L Didcock; D F Young; S Goodbourn; R E Randall
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

6.  Interferon induction by viruses. XIV. Development of interferon inducibility and its inhibition in chick embryo cells "aged" in vitro.

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Journal:  J Interferon Res       Date:  1985

7.  Infectious influenza A and B virus variants with long carboxyl terminal deletions in the NS1 polypeptides.

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Journal:  Virology       Date:  1987-02       Impact factor: 3.616

8.  Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines.

Authors:  M O Diaz; S Ziemin; M M Le Beau; P Pitha; S D Smith; R R Chilcote; J D Rowley
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

9.  Complete nucleotide sequence of the influenza A/PR/8/34 virus NS gene and comparison with the NS genes of the A/Udorn/72 and A/FPV/Rostock/34 strains.

Authors:  M Baez; R Taussig; J J Zazra; J F Young; P Palese; A Reisfeld; A M Skalka
Journal:  Nucleic Acids Res       Date:  1980-12-11       Impact factor: 16.971

10.  Biological functions of the NS1 protein of an influenza B virus mutant which has a long carboxyl terminal deletion.

Authors:  T Tanaka; T Odagiri; K Tobita
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574
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  160 in total

1.  The Ebola virus VP35 protein functions as a type I IFN antagonist.

Authors:  C F Basler; X Wang; E Mühlberger; V Volchkov; J Paragas; H D Klenk; A García-Sastre; P Palese
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

2.  Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon.

Authors:  X Wang; M Li; H Zheng; T Muster; P Palese; A A Beg; A García-Sastre
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

Review 3.  Influenza vaccines: present and future.

Authors:  Peter Palese; Adolfo García-Sastre
Journal:  J Clin Invest       Date:  2002-07       Impact factor: 14.808

4.  Establishment of a chimeric, replication-deficient influenza A virus vector by modulation of splicing efficiency.

Authors:  Markus Wolschek; Elisabeth Samm; Helena Seper; Sanda Sturlan; Irina Kuznetsova; Cornelia Schwager; Alexandra Khassidov; Christian Kittel; Thomas Muster; Andrej Egorov; Michael Bergmann
Journal:  J Virol       Date:  2010-12-22       Impact factor: 5.103

5.  Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3.

Authors:  Mario Barro; John T Patton
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-01       Impact factor: 11.205

6.  Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses.

Authors:  Christina Ehrhardt; Thorsten Wolff; Stephan Ludwig
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

7.  Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus.

Authors:  C R Baskin; H Bielefeldt-Ohmann; A García-Sastre; T M Tumpey; N Van Hoeven; V S Carter; M J Thomas; S Proll; A Solórzano; R Billharz; J L Fornek; S Thomas; C-H Chen; E A Clark; Kaja Murali-Krishna; M G Katze
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

8.  Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza.

Authors:  John Steel; Anice C Lowen; Lindomar Pena; Matthew Angel; Alicia Solórzano; Randy Albrecht; Daniel R Perez; Adolfo García-Sastre; Peter Palese
Journal:  J Virol       Date:  2008-12-10       Impact factor: 5.103

Review 9.  Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits.

Authors:  Fatma Berri; Vuong Ba Lê; Martine Jandrot-Perrus; Bruno Lina; Béatrice Riteau
Journal:  Cell Mol Life Sci       Date:  2013-10-04       Impact factor: 9.261

10.  Extending the cytoplasmic tail of the influenza a virus M2 protein leads to reduced virus replication in vivo but not in vitro.

Authors:  Wai-Hong Wu; Andrew Pekosz
Journal:  J Virol       Date:  2007-11-07       Impact factor: 5.103
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