Literature DB >> 10722887

Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay.

A M Jeffrey1, G M Williams.   

Abstract

The non-nutritive sweeteners acesulfame-K, aspartame, cyclamate, saccharin and sucralose were tested for DNA damaging activity in the rat hepatocyte/DNA repair assay. Using hepatocytes from F344 and Sprague-Dawley male rats, all were inactive despite strong responses for the positive control, 2-aminofluorene.

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Year:  2000        PMID： 10722887     DOI： 10.1016/s0278-6915(99)00163-5

Source DB:  PubMed          Journal:  Food Chem Toxicol        ISSN： 0278-6915            Impact factor:   6.023


  7 in total

1.  In vivo cytogenetic studies on aspartame.

Authors:  Entissar S Alsuhaibani
Journal:  Comp Funct Genomics       Date:  2010-06-20

2.  Aspartame downregulates 3T3-L1 differentiation.

Authors:  Muthuraman Pandurangan; Jeongeun Park; Eunjung Kim
Journal:  In Vitro Cell Dev Biol Anim       Date:  2014-06-25       Impact factor: 2.416

Review 3.  Lifestyle issues and genitourinary tumours.

Authors:  Frank Sommer; Theo Klotz; Bernd J Schmitz-Dräger
Journal:  World J Urol       Date:  2003-12-12       Impact factor: 4.226

4.  A review of the genotoxic and carcinogenic effects of aspartame: does it safe or not?

Authors:  Serkan Yılmaz; Aslı Uçar
Journal:  Cytotechnology       Date:  2014-02-08       Impact factor: 2.058

5.  First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats.

Authors:  Morando Soffritti; Fiorella Belpoggi; Davide Degli Esposti; Luca Lambertini; Eva Tibaldi; Anna Rigano
Journal:  Environ Health Perspect       Date:  2006-03       Impact factor: 9.031

Review 6.  Sucralose Non-Carcinogenicity: A Review of the Scientific and Regulatory Rationale.

Authors:  Colin Berry; David Brusick; Samuel M Cohen; Jerry F Hardisty; V Lee Grotz; Gary M Williams
Journal:  Nutr Cancer       Date:  2016-09-21       Impact factor: 2.900

Review 7.  Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners.

Authors:  Eleonora Moriconi; Alessandra Feraco; Vincenzo Marzolla; Marco Infante; Mauro Lombardo; Andrea Fabbri; Massimiliano Caprio
Journal:  Front Endocrinol (Lausanne)       Date:  2020-07-16       Impact factor: 5.555
  7 in total

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