OBJECTIVE: To investigate whether unilateral pallidotomy affects cognitive and behavioral functioning. METHODS: At baseline and after 6 months we assessed neuropsychological functioning in 35 patients with advanced PD. After baseline examination, patients were randomized to pallidotomy within 1 month (6 left-sided, 13 right-sided) or to pallidotomy after follow-up assessment 6 months later (n = 16; control group). We performed neuropsychological tests of language, visuospatial function, memory, attention, and executive functions. Self ratings and proxy ratings of memory problems and dysexecutive symptoms were also collected. RESULTS: No significant differences over time were found between pallidotomy and control groups, with the exception of a decrease of verbal fluency in the left-sided pallidotomy group. CONCLUSIONS:Unilateral pallidotomy is relatively safe with respect to cognition and behavior. Left-sided pallidotomy may lead to minor deterioration in verbal fluency. The sample size of this study is too small, however, to rule out the possibility of infrequent but clinically important side effects.
RCT Entities:
OBJECTIVE: To investigate whether unilateral pallidotomy affects cognitive and behavioral functioning. METHODS: At baseline and after 6 months we assessed neuropsychological functioning in 35 patients with advanced PD. After baseline examination, patients were randomized to pallidotomy within 1 month (6 left-sided, 13 right-sided) or to pallidotomy after follow-up assessment 6 months later (n = 16; control group). We performed neuropsychological tests of language, visuospatial function, memory, attention, and executive functions. Self ratings and proxy ratings of memory problems and dysexecutive symptoms were also collected. RESULTS: No significant differences over time were found between pallidotomy and control groups, with the exception of a decrease of verbal fluency in the left-sided pallidotomy group. CONCLUSIONS: Unilateral pallidotomy is relatively safe with respect to cognition and behavior. Left-sided pallidotomy may lead to minor deterioration in verbal fluency. The sample size of this study is too small, however, to rule out the possibility of infrequent but clinically important side effects.
Authors: Harriet M M Smeding; Rianne A J Esselink; Ben Schmand; Marthe Koning-Haanstra; Ilse Nijhuis; Elze M Wijnalda; Johannes D Speelman Journal: J Neurol Date: 2005-02 Impact factor: 4.849
Authors: M F Contarino; A Daniele; A H Sibilia; L M A Romito; A R Bentivoglio; G Gainotti; A Albanese Journal: J Neurol Neurosurg Psychiatry Date: 2006-05-11 Impact factor: 10.154
Authors: R M de Bie; P R Schuurman; D A Bosch; R J de Haan; B Schmand; J D Speelman Journal: J Neurol Neurosurg Psychiatry Date: 2001-09 Impact factor: 10.154
Authors: E J Meeuwsen; P German; R J F Melis; E M Adang; G A Golüke-Willemse; P F Krabbe; B J de Leest; F H J M van Raak; C J M Schölzel-Dorenbos; M C Visser; C A Wolfs; S Vliek; M G M Olde Rikkert Journal: J Nutr Health Aging Date: 2009-03 Impact factor: 4.075
Authors: A L Cheesman; R A Barker; S J G Lewis; T W Robbins; A M Owen; D J Brooks Journal: J Neurol Neurosurg Psychiatry Date: 2005-09 Impact factor: 10.154