Literature DB >> 10720100

Peptide nucleic acids: on the road to new gene therapeutic drugs.

P E Nielsen1.   

Abstract

Peptide nucleic acid (PNA) is a DNA mimic based on a pseudopeptide (polyamide) backbone. PNA oligomers bind strongly and with high sequence specificity to complementary targets in RNA (or DNA), and they show very high biological stability. Furthermore, studies in cell free systems have demonstrated potent antisense (inhibition of translation) and antigene (inhibition of transcription) activity of PNA. Recently, several studies reporting methods for cellular delivery of PNA as well as antisense effects of PNA in cells ex vivo and in rats have appeared. The potential of developing PNA derived gene therapeutic drugs is discussed.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10720100     DOI： 10.1034/j.1600-0773.2000.pto860102.x

Source DB:  PubMed          Journal:  Pharmacol Toxicol        ISSN： 0901-9928


  9 in total

1.  Ribozyme-based gene-inactivation systems require a fine comprehension of their substrate specificities; the case of delta ribozyme.

Authors:  Lucien Junior Bergeron; Jonathan Ouellet; Jean-Pierre Perreault
Journal:  Curr Med Chem       Date:  2003-12       Impact factor: 4.530

2.  Functional characterization of the SOFA delta ribozyme.

Authors:  Lucien Junior Bergeron; Cédric Reymond; Jean-Pierre Perreault
Journal:  RNA       Date:  2005-10-26       Impact factor: 4.942

3.  Antisense phosphorodiamidate morpholino oligomer length and target position effects on gene-specific inhibition in Escherichia coli.

Authors:  Jesse Deere; Pat Iversen; Bruce L Geller
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

4.  Orientation preferences of backbone secondary amide functional groups in peptide nucleic acid complexes: quantum chemical calculations reveal an intrinsic preference of cationic D-amino acid-based chiral PNA analogues for the P-form.

Authors:  Christopher M Topham; Jeremy C Smith
Journal:  Biophys J       Date:  2006-10-27       Impact factor: 4.033

5.  Lipidated α/α-AA heterogeneous peptides as antimicrobial agents.

Authors:  Sylvia Singh; Alekhya Nimmagadda; Ma Su; Minghui Wang; Peng Teng; Jianfeng Cai
Journal:  Eur J Med Chem       Date:  2018-06-05       Impact factor: 6.514

6.  Localization and dynamics of small circular DNA in live mammalian nuclei.

Authors:  Giulia Mearini; Peter E Nielsen; Frank O Fackelmayer
Journal:  Nucleic Acids Res       Date:  2004-05-11       Impact factor: 16.971

7.  Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies.

Authors:  Kelsey R Beavers; Thomas A Werfel; Tianwei Shen; Taylor E Kavanaugh; Kameron V Kilchrist; Jeremy W Mares; Joshua S Fain; Carrie B Wiese; Kasey C Vickers; Sharon M Weiss; Craig L Duvall
Journal:  Adv Mater       Date:  2016-07-06       Impact factor: 30.849

Review 8.  Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination.

Authors:  Ai-Ming Yu; Mei-Juan Tu
Journal:  Pharmacol Ther       Date:  2021-08-14       Impact factor: 13.400

9.  Hairpin ribozyme-antisense RNA constructs can act as molecular Lassos.

Authors:  Anne Dallas; Svetlana V Balatskaya; Tai-Chih Kuo; Heini Ilves; Alexander V Vlassov; Roger L Kaspar; Kevin O Kisich; Sergei A Kazakov; Brian H Johnston
Journal:  Nucleic Acids Res       Date:  2008-10-25       Impact factor: 16.971
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.