Literature DB >> 10716989

The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure.

P R Mittl1, C Deillon, D Sargent, N Liu, S Klauser, R M Thomas, B Gutte, M G Grütter.   

Abstract

The question of whether a protein whose natural sequence is inverted adopts a stable fold is still under debate. We have determined the 2. 1-A crystal structure of the retro-GCN4 leucine zipper. In contrast to the two-stranded helical coiled-coil GCN4 leucine zipper, the retro-leucine zipper formed a very stable, parallel four-helix bundle, which now lends itself to further structural and functional studies.

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Year:  2000        PMID： 10716989      PMCID： PMC15968          DOI： 10.1073/pnas.97.6.2562

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Efficient anisotropic refinement of macromolecular structures using FFT.

Authors:  G N Murshudov; A A Vagin; A Lebedev; K S Wilson; E J Dodson
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1999-01-01

2.  Improved methods for building protein models in electron density maps and the location of errors in these models.

Authors:  T A Jones; J Y Zou; S W Cowan; M Kjeldgaard
Journal:  Acta Crystallogr A       Date:  1991-03-01       Impact factor: 2.290

3.  Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.

Authors:  A Nicholls; K A Sharp; B Honig
Journal:  Proteins       Date:  1991

4.  Crystallography & NMR system: A new software suite for macromolecular structure determination.

Authors:  A T Brünger; P D Adams; G M Clore; W L DeLano; P Gros; R W Grosse-Kunstleve; J S Jiang; J Kuszewski; M Nilges; N S Pannu; R J Read; L M Rice; T Simonson; G L Warren
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1998-09-01

Review 5.  Supercoiled protein motifs: the collagen triple-helix and the alpha-helical coiled coil.

Authors:  K Beck; B Brodsky
Journal:  J Struct Biol       Date:  1998       Impact factor: 2.867

6.  An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.

Authors:  R M Esnouf
Journal:  J Mol Graph Model       Date:  1997-04       Impact factor: 2.518

7.  Oligomerization properties of GCN4 leucine zipper e and g position mutants.

Authors:  X Zeng; H Zhu; H A Lashuel; J C Hu
Journal:  Protein Sci       Date:  1997-10       Impact factor: 6.725

8.  A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants.

Authors:  P B Harbury; T Zhang; P S Kim; T Alber
Journal:  Science       Date:  1993-11-26       Impact factor: 47.728

9.  Synthesis and properties of the peptide corresponding to the mutant form of the leucine zipper of the transcriptional activator GCN4 from yeast.

Authors:  S A Potekhin; V N Medvedkin; I A Kashparov
Journal:  Protein Eng       Date:  1994-09

10.  Surface salt bridges stabilize the GCN4 leucine zipper.

Authors:  E J Spek; A H Bui; M Lu; N R Kallenbach
Journal:  Protein Sci       Date:  1998-11       Impact factor: 6.725
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  26 in total

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Journal:  RNA       Date:  2010-07-30       Impact factor: 4.942

2.  Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.

Authors:  Sergey S Seregin; Yasser A Aldhamen; Daniel M Appledorn; Zachary C Hartman; Nathaniel J Schuldt; Jeannine Scott; Sarah Godbehere; Haixiang Jiang; Michael M Frank; Andrea Amalfitano
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3.  Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution.

Authors:  Maneesh K Yadav; Luke J Leman; Daniel J Price; Charles L Brooks; C David Stout; M Reza Ghadiri
Journal:  Biochemistry       Date:  2006-04-11       Impact factor: 3.162

4.  Molecular dynamics with the United-residue force field: ab initio folding simulations of multichain proteins.

Authors:  Ana V Rojas; Adam Liwo; Harold A Scheraga
Journal:  J Phys Chem B       Date:  2007-01-11       Impact factor: 2.991

5.  Design of fast proteolysis-based signaling and logic circuits in mammalian cells.

Authors:  Tina Fink; Jan Lonzarić; Arne Praznik; Tjaša Plaper; Estera Merljak; Katja Leben; Nina Jerala; Tina Lebar; Žiga Strmšek; Fabio Lapenta; Mojca Benčina; Roman Jerala
Journal:  Nat Chem Biol       Date:  2018-12-10       Impact factor: 15.040

6.  A region of the sulfonylurea receptor critical for a modulation of ATP-sensitive K(+) channels by G-protein betagamma-subunits.

Authors:  Y Wada; T Yamashita; K Imai; R Miura; K Takao; M Nishi; H Takeshima; T Asano; R Morishita; K Nishizawa; S Kokubun; T Nukada
Journal:  EMBO J       Date:  2000-09-15       Impact factor: 11.598

7.  Sequence Reversal Prevents Chain Collapse and Yields Heat-Sensitive Intrinsic Disorder.

Authors:  Lance R English; Alexander Tischer; Aysha K Demeler; Borries Demeler; Steven T Whitten
Journal:  Biophys J       Date:  2018-07-17       Impact factor: 4.033

8.  An algorithm to find all palindromic sequences in proteins.

Authors:  N Prasanth; M Kirti Vaishnavi; K Sekar
Journal:  J Biosci       Date:  2013-03       Impact factor: 1.826

9.  The leucine zipper domains of the transcription factors GCN4 and c-Jun have ribonuclease activity.

Authors:  Yaroslav Nikolaev; Christine Deillon; Stefan R K Hoffmann; Laurent Bigler; Sebastian Friess; Renato Zenobi; Konstantin Pervushin; Peter Hunziker; Bernd Gutte
Journal:  PLoS One       Date:  2010-05-21       Impact factor: 3.240

10.  Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes: implications for classification of enzyme function.

Authors:  Daniel E Almonacid; Emmanuel R Yera; John B O Mitchell; Patricia C Babbitt
Journal:  PLoS Comput Biol       Date:  2010-03-12       Impact factor: 4.475
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