| Literature DB >> 10716257 |
J A Nicoll1, R E Mrak, D I Graham, J Stewart, G Wilcock, S MacGowan, M M Esiri, L S Murray, D Dewar, S Love, T Moss, W S Griffin.
Abstract
Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred even greater risk (odds ratio, 10.8). IL-1 genotypes may confer risk for Alzheimer's disease through IL-1 overexpression and IL-1-driven neurodegenerative cascades.Entities:
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Year: 2000 PMID： 10716257 PMCID： PMC3833599
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422