Literature DB >> 10716224

Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellum.

A Berthele1, S Platzer, D J Laurie, S Weis, B Sommer, W Zieglgänsberger, B Conrad, T R Tölle.   

Abstract

The expression of metabotropic glutamate receptor (mGluR) mRNAs in the human cerebellar neocortex was investigated using in situ hybridization. mGluR1, 3 and 4 mRNAs were most abundant and widely distributed, whereas mGluR2, 5 and 7 mRNA expression was circumscript. mRNAs coding for mGluR1, 3, 4 and 7 were expressed in Purkinje cells. mGluR1 and 4 mRNAs detectable in granule cells and mGluR1, 2, 3, 4 and 7 mRNAs in Golgi cells. mGluR5 mRNA was detectable in putative Bergmann glia as well as mGluR3 mRNA, which was widely expressed in glial cells. mGluR8 mRNA expression was very low in a subset of stellate/basket cells of the molecular layer whereas mGluR6 mRNA was not detectable in the cerebellar cortex.

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Year:  1999        PMID： 10716224     DOI： 10.1097/00001756-199912160-00026

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  24 in total

1.  Group III metabotropic glutamate receptors as autoreceptors in the cerebellar cortex.

Authors:  Matthias Lorez; Urs Humbel; Marie-Claire Pflimlin; James N C Kew
Journal:  Br J Pharmacol       Date:  2003-02       Impact factor: 8.739

2.  Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder.

Authors:  Josephine Elia; Joseph T Glessner; Kai Wang; Nagahide Takahashi; Corina J Shtir; Dexter Hadley; Patrick M A Sleiman; Haitao Zhang; Cecilia E Kim; Reid Robison; Gholson J Lyon; James H Flory; Jonathan P Bradfield; Marcin Imielinski; Cuiping Hou; Edward C Frackelton; Rosetta M Chiavacci; Takeshi Sakurai; Cara Rabin; Frank A Middleton; Kelly A Thomas; Maria Garris; Frank Mentch; Christine M Freitag; Hans-Christoph Steinhausen; Alexandre A Todorov; Andreas Reif; Aribert Rothenberger; Barbara Franke; Eric O Mick; Herbert Roeyers; Jan Buitelaar; Klaus-Peter Lesch; Tobias Banaschewski; Richard P Ebstein; Fernando Mulas; Robert D Oades; Joseph Sergeant; Edmund Sonuga-Barke; Tobias J Renner; Marcel Romanos; Jasmin Romanos; Andreas Warnke; Susanne Walitza; Jobst Meyer; Haukur Pálmason; Christiane Seitz; Sandra K Loo; Susan L Smalley; Joseph Biederman; Lindsey Kent; Philip Asherson; Richard J L Anney; J William Gaynor; Philip Shaw; Marcella Devoto; Peter S White; Struan F A Grant; Joseph D Buxbaum; Judith L Rapoport; Nigel M Williams; Stanley F Nelson; Stephen V Faraone; Hakon Hakonarson
Journal:  Nat Genet       Date:  2011-12-04       Impact factor: 38.330

3.  Group I mGluR-induced epileptogenesis: distinct and overlapping roles of mGluR1 and mGluR5 and implications for antiepileptic drug design.

Authors:  Robert K S Wong; Riccardo Bianchi; Shih-Chieh Chuang; Lisa R Merlin
Journal:  Epilepsy Curr       Date:  2005 Mar-Apr       Impact factor: 7.500

Review 4.  Driving cellular plasticity and survival through the signal transduction pathways of metabotropic glutamate receptors.

Authors:  Kenneth Maiese; Zhao Zhong Chong; Faqi Li
Journal:  Curr Neurovasc Res       Date:  2005-12       Impact factor: 1.990

5.  Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study.

Authors:  Alexandra Deschwanden; Beata Karolewicz; Anteneh M Feyissa; Valerie Treyer; Simon M Ametamey; Anass Johayem; Cyrill Burger; Yves P Auberson; Judit Sovago; Craig A Stockmeier; Alfred Buck; Gregor Hasler
Journal:  Am J Psychiatry       Date:  2011-04-15       Impact factor: 18.112

6.  Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors.

Authors:  Igor Ponomarev; Rajani Maiya; Mark T Harnett; Gwen L Schafer; Andrey E Ryabinin; Yuri A Blednov; Hitoshi Morikawa; Stephen L Boehm; Gregg E Homanics; Ari E Berman; Ari Berman; Kerrie H Lodowski; Susan E Bergeson; R Adron Harris
Journal:  J Neurosci       Date:  2006-05-24       Impact factor: 6.167

Review 7.  Metabotropic glutamate receptor ligands as potential therapeutics for addiction.

Authors:  M Foster Olive
Journal:  Curr Drug Abuse Rev       Date:  2009-01

8.  Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [11C]ABP688 positron emission tomography.

Authors:  Funda Akkus; Simon M Ametamey; Valerie Treyer; Cyrill Burger; Anass Johayem; Daniel Umbricht; Baltazar Gomez Mancilla; Judit Sovago; Alfred Buck; Gregor Hasler
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-17       Impact factor: 11.205

9.  Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [11 C]ABP688 PET imaging.

Authors:  William B Mathews; Hiroto Kuwabara; Kirstie Stansfield; Heather Valentine; Mohab Alexander; Anil Kumar; John Hilton; Robert F Dannals; Dean F Wong; Fabrizio Gasparini
Journal:  Synapse       Date:  2014-08-19       Impact factor: 2.562

Review 10.  Therapeutic promise and principles: metabotropic glutamate receptors.

Authors:  Kenneth Maiese; Zhao Zhong Chong; Yan Chen Shang; Jinling Hou
Journal:  Oxid Med Cell Longev       Date:  2008 Oct-Dec       Impact factor: 6.543
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