| Literature DB >> 10714496 |
S Menzler1, J A Bikker, N Suman-Chauhan, D C Horwell.
Abstract
Omega-conotoxin MVIIA, a highly potent antagonist of the N-type voltage sensitive calcium channel, has shown utility in several models of pain and ischemia. We report a series of three alkylphenyl ether based analogues which mimic three key amino acids of the toxin. Two of the compounds have been found to exhibit IC50 values of 2.7 and 3.3 microM at the human N-type voltage sensitive calcium channel.Entities:
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Year: 2000 PMID： 10714496 DOI： 10.1016/s0960-894x(99)00699-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823