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Literature DB >> 10710710

Micro-mechanical measurement of the torsional modulus of DNA.

Abstract

The torsional modulus C of DNA is determined from the difference between the work of stretching a single overwound molecule and the work done in stretching one underwound by the same number of turns. The value obtained C/kBT = 86 +/- 10 nm is within the range (75 +/- 25 nm) estimated by more indirect methods.

Mesh：

Substances：
DNA, Superhelical

Year: 1999 PMID： 10710710 DOI： 10.1023/a:1003772626927

Source DB: PubMed Journal: Genetica ISSN： 0016-6707 Impact factor: 1.082

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Cited

17 in total

1. Force and kinetic barriers to unzipping of the DNA double helix.

Authors: S Cocco; R Monasson; J F Marko
Journal: Proc Natl Acad Sci U S A Date: 2001-07-10 Impact factor: 11.205

2. Promoter unwinding and promoter clearance by RNA polymerase: detection by single-molecule DNA nanomanipulation.

Authors: Andrey Revyakin; Richard H Ebright; Terence R Strick
Journal: Proc Natl Acad Sci U S A Date: 2004-03-22 Impact factor: 11.205

3. PREDICTED EFFECTS OF LOCAL CONFORMATIONAL COUPLING AND EXTERNAL RESTRAINTS ON THE TORSIONAL PROPERTIES OF SINGLE DNA MOLECULES.

Authors: Atsushi Matsumoto; Wilma K Olson
Journal: Multiscale Model Simul Date: 2006 Impact factor: 1.930

10. In the absence of writhe, DNA relieves torsional stress with localized, sequence-dependent structural failure to preserve B-form.

Authors: Graham L Randall; Lynn Zechiedrich; B Montgomery Pettitt
Journal: Nucleic Acids Res Date: 2009-07-08 Impact factor: 16.971

Micro-mechanical measurement of the torsional modulus of DNA.

1. Force and kinetic barriers to unzipping of the DNA double helix.

2. Promoter unwinding and promoter clearance by RNA polymerase: detection by single-molecule DNA nanomanipulation.

3. PREDICTED EFFECTS OF LOCAL CONFORMATIONAL COUPLING AND EXTERNAL RESTRAINTS ON THE TORSIONAL PROPERTIES OF SINGLE DNA MOLECULES.

4. Abrupt buckling transition observed during the plectoneme formation of individual DNA molecules.

5. Direct measurements of torque during Holliday junction migration.

6. DNA supercoiling: a regulatory signal for the λ repressor.

Review 7. Supercoiling biases the formation of loops involved in gene regulation.

8. An optical apparatus for rotation and trapping.

9. Mechanically unzipping dsDNA with built-in sequence inhomogeneities and bound proteins.

10. In the absence of writhe, DNA relieves torsional stress with localized, sequence-dependent structural failure to preserve B-form.