Literature DB >> 10707260

Antituberculosis activity of certain antifungal and antihelmintic drugs.

Z Sun1, Y Zhang.   

Abstract

A panel of antifungal and antihelmintic drugs was tested for activity against Mycobacterium tuberculosis in vitro. Antifungal drugs, miconazole, 2-nitroimidazole, clotrimazole, and the antihelmintic drug niclosamide were found to have significant antituberculosis activity, with minimal inhibitory concentrations (MICs) between 1 and 10 micrograms/ml. Niclosamide and 2-nitroimidazole also had activity against stationary phase tubercle bacilli. Further testing of these drugs and their derivatives in vitro and in vivo appears to be warranted.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10707260     DOI： 10.1054/tuld.1999.0212

Source DB:  PubMed          Journal:  Tuber Lung Dis        ISSN： 0962-8479


  23 in total

1.  Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria.

Authors:  Christopher H Miller; Shahista Nisa; Sandi Dempsey; Cameron Jack; Ronan O'Toole
Journal:  Antimicrob Agents Chemother       Date:  2009-09-28       Impact factor: 5.191

2.  Detection of inhibitors of phenotypically drug-tolerant Mycobacterium tuberculosis using an in vitro bactericidal screen.

Authors:  Ian M Bassett; Shichun Lun; William R Bishai; Haidan Guo; Joanna R Kirman; Mudassar Altaf; Ronan F O'Toole
Journal:  J Microbiol       Date:  2013-06-25       Impact factor: 3.422

3.  Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.

Authors:  Sang Hyun Cho; Saradee Warit; Baojie Wan; Chang Hwa Hwang; Guido F Pauli; Scott G Franzblau
Journal:  Antimicrob Agents Chemother       Date:  2007-01-08       Impact factor: 5.191

4.  On the photooxidation of the multifunctional drug niclosamide. A kinetic study in the presence of vitamin B2 and visible light.

Authors:  José Natera; Eduardo Gatica; Cecilia Challier; David Possetto; Walter Massad; Sandra Miskoski; Adriana Pajares; Norman A García
Journal:  Redox Rep       Date:  2015-04-21       Impact factor: 4.412

Review 5.  Potential drug targets in the Mycobacterium tuberculosis cytochrome P450 system.

Authors:  Paul R Ortiz de Montellano
Journal:  J Inorg Biochem       Date:  2018-01-12       Impact factor: 4.155

Review 6.  Nitroimidazoles for the treatment of TB: past, present and future.

Authors:  Tathagata Mukherjee; Helena Boshoff
Journal:  Future Med Chem       Date:  2011-09       Impact factor: 3.808

7.  Salicylate reduces susceptibility of Mycobacterium tuberculosis to multiple antituberculosis drugs.

Authors:  Alain Schaller; Zhonghe Sun; Yongping Yang; Akos Somoskovi; Ying Zhang
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

8.  New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing.

Authors:  Francesco Imperi; Francesco Massai; Cejoice Ramachandran Pillai; Francesca Longo; Elisabetta Zennaro; Giordano Rampioni; Paolo Visca; Livia Leoni
Journal:  Antimicrob Agents Chemother       Date:  2012-12-17       Impact factor: 5.191

9.  New anti-tuberculosis agents amongst known drugs.

Authors:  Kathryn E A Lougheed; Debra L Taylor; Simon A Osborne; Justin S Bryans; Roger S Buxton
Journal:  Tuberculosis (Edinb)       Date:  2009-08-20       Impact factor: 3.131

10.  Design and Synthesis of Molecular Scaffolds with Anti-infective Activity.

Authors:  Junjia Liu; T Aaron Bedell; Julian G West; Erik J Sorensen
Journal:  Tetrahedron       Date:  2016-01-28       Impact factor: 2.457
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.