Literature DB >> 19786608

Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria.

Christopher H Miller1, Shahista Nisa, Sandi Dempsey, Cameron Jack, Ronan O'Toole.   

Abstract

In this study, application of a dual absorbance/fluorescence assay to a chemical library screen identified several previously unknown inhibitors of mycobacteria. In addition, growth conditions had a significant effect on the activity profile of the library. Some inhibitors such as Se-methylselenocysteine were detected only when screening was performed under nutrient-limited culture conditions as opposed to nutrient-rich culture conditions. We propose that multiple culture condition library screening is required for complete inhibitory profiling and for maximal antimycobacterial compound detection.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19786608      PMCID： PMC2786345          DOI： 10.1128/AAC.00803-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.

Authors: 
Journal:  J Biomol Screen       Date:  1999

2.  Construction and phenotypic characterization of an auxotrophic mutant of Mycobacterium tuberculosis defective in L-arginine biosynthesis.

Authors:  Bhavna G Gordhan; Debbie A Smith; Heidi Alderton; Ruth A McAdam; Gregory J Bancroft; Valerie Mizrahi
Journal:  Infect Immun       Date:  2002-06       Impact factor: 3.441

3.  Genetic analysis of the Mycobacterium smegmatis rpsL promoter.

Authors:  T J Kenney; G Churchward
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

Review 4.  Chemical forms of selenium for cancer prevention.

Authors:  Rizky Abdulah; Kaori Miyazaki; Minato Nakazawa; Hiroshi Koyama
Journal:  J Trace Elem Med Biol       Date:  2005-10-24       Impact factor: 3.849

5.  Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling.

Authors:  Joanna C Betts; Pauline T Lukey; Linda C Robb; Ruth A McAdam; Ken Duncan
Journal:  Mol Microbiol       Date:  2002-02       Impact factor: 3.501

6.  Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole.

Authors:  Adeline Burguière; Paul G Hitchen; Lynn G Dover; Anne Dell; Gurdyal S Besra
Journal:  Microbiology       Date:  2005-06       Impact factor: 2.777

Review 7.  Selenium and anticarcinogenesis: underlying mechanisms.

Authors:  Matthew I Jackson; Gerald F Combs
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2008-11       Impact factor: 4.294

8.  Visualisation of zebrafish infection by GFP-labelled Vibrio anguillarum.

Authors:  Ronan O'Toole; Jonas Von Hofsten; Roland Rosqvist; Per-Erik Olsson; Hans Wolf-Watz
Journal:  Microb Pathog       Date:  2004-07       Impact factor: 3.738

9.  Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms?

Authors:  Tobias Hampshire; Shamit Soneji; Joanna Bacon; Brian W James; Jason Hinds; Ken Laing; Richard A Stabler; Philip D Marsh; Philip D Butcher
Journal:  Tuberculosis (Edinb)       Date:  2004       Impact factor: 3.131

10.  Adaptation of Mycobacterium smegmatis to stationary phase.

Authors:  M J Smeulders; J Keer; R A Speight; H D Williams
Journal:  J Bacteriol       Date:  1999-01       Impact factor: 3.490
View more
  7 in total

1.  Detection of inhibitors of phenotypically drug-tolerant Mycobacterium tuberculosis using an in vitro bactericidal screen.

Authors:  Ian M Bassett; Shichun Lun; William R Bishai; Haidan Guo; Joanna R Kirman; Mudassar Altaf; Ronan F O'Toole
Journal:  J Microbiol       Date:  2013-06-25       Impact factor: 3.422

2.  Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery.

Authors:  Shahista Nisa; Marian C J Blokpoel; Brian D Robertson; Joel D A Tyndall; Shichun Lun; William R Bishai; Ronan O'Toole
Journal:  J Antimicrob Chemother       Date:  2010-09-01       Impact factor: 5.790

Review 3.  A systems approach to infectious disease.

Authors:  Manon Eckhardt; Judd F Hultquist; Robyn M Kaake; Ruth Hüttenhain; Nevan J Krogan
Journal:  Nat Rev Genet       Date:  2020-02-14       Impact factor: 53.242

4.  Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis.

Authors:  Emma A Earl; Mudassar Altaf; Rekha V Murikoli; Simon Swift; Ronan O'Toole
Journal:  BMC Complement Altern Med       Date:  2010-06-10       Impact factor: 3.659

5.  Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis.

Authors:  Julie V Early; Allen Casey; Maria Angeles Martinez-Grau; Isabel C Gonzalez Valcarcel; Michal Vieth; Juliane Ollinger; Mai Ann Bailey; Torey Alling; Megan Files; Yulia Ovechkina; Tanya Parish
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191

6.  Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes.

Authors:  Arielle Butts; Christian DeJarnette; Tracy L Peters; Josie E Parker; Morgan E Kerns; Karen E Eberle; Steve L Kelly; Glen E Palmer
Journal:  mSphere       Date:  2017-10-04       Impact factor: 4.389

7.  An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice.

Authors:  Pamela A Harvey; Corrella S Detweiler; Jack R McLeod
Journal:  Microbiol Spectr       Date:  2021-06-30
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.