Literature DB >> 10704024

Assay of beta-hematin formation by malaria parasite.

A V Pandey1, N Singh, B L Tekwani, S K Puri, V S Chauhan.   

Abstract

Novel leads are urgently required for designing antimalarials due to the reduced efficacy of presently available drugs. The malaria parasite has a unique reaction of heme polymerization, which has attracted much attention in the recent past as a target for the design of antimalarial drugs. The process is hampered by non-availability of a proper assay method. Currently available methods are cumbersome and require advanced instrumentation or radioactive substrates. Here, we are describing an assay for hemozoin formation that is simple and reproducible. This assay has routinely been used by us for the identification of potential compounds with antimalarial activity.

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Year:  1999        PMID： 10704024     DOI： 10.1016/s0731-7085(99)00021-7

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  9 in total

1.  Mechanism of malarial haem detoxification inhibition by chloroquine.

Authors:  A V Pandey; H Bisht; V K Babbarwal; J Srivastava; K C Pandey; V S Chauhan
Journal:  Biochem J       Date:  2001-04-15       Impact factor: 3.857

2.  Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds.

Authors:  Steven J Burgess; Jane X Kelly; Shawheen Shomloo; Sergio Wittlin; Reto Brun; Katherine Liebmann; David H Peyton
Journal:  J Med Chem       Date:  2010-09-09       Impact factor: 7.446

3.  Antimalarial Activity of Small-Molecule Benzothiazole Hydrazones.

Authors:  Souvik Sarkar; Asim A Siddiqui; Shubhra J Saha; Rudranil De; Somnath Mazumder; Chinmoy Banerjee; Mohd S Iqbal; Shiladitya Nag; Susanta Adhikari; Uday Bandyopadhyay
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

4.  In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum.

Authors:  Khurshida Begum; Hye-Sook Kim; Veena Kumar; Igor Stojiljkovic; Yusuke Wataya
Journal:  Parasitol Res       Date:  2003-03-12       Impact factor: 2.289

5.  Antiplasmodial activity of [(aryl)arylsulfanylmethyl]Pyridine.

Authors:  Sanjay Kumar; Sajal Kumar Das; Sumanta Dey; Pallab Maity; Mithu Guha; Vinay Choubey; Gautam Panda; Uday Bandyopadhyay
Journal:  Antimicrob Agents Chemother       Date:  2007-11-19       Impact factor: 5.191

6.  Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth.

Authors:  Alexander P Gorka; John N Alumasa; Katy S Sherlach; Lauren M Jacobs; Katherine B Nickley; Jonathan P Brower; Angel C de Dios; Paul D Roepe
Journal:  Antimicrob Agents Chemother       Date:  2012-10-31       Impact factor: 5.191

7.  Dendrimeric template of Plasmodium falciparum histidine rich protein II repeat motifs bearing Asp→Asn mutation exhibits heme binding and β-hematin formation.

Authors:  Pinky Kumari; Dinkar Sahal; Virander S Chauhan
Journal:  PLoS One       Date:  2014-11-14       Impact factor: 3.240

8.  In vitro anti-malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes.

Authors:  Shweta Sinha; Daniela I Batovska; Bikash Medhi; B D Radotra; Ashish Bhalla; Nadezhda Markova; Rakesh Sehgal
Journal:  Malar J       Date:  2019-12-16       Impact factor: 2.979

9.  Antimalarial Activities of (Z)-2-(Nitroheteroarylmethylene)-3(2H)-Benzofuranone Derivatives: In Vitro and In Vivo Assessment and β-Hematin Formation Inhibition Activity.

Authors:  Latifeh Navidpour; Kelly Chibale; Somayeh Esmaeili; Azadeh Ghiaee; Narges Hadj-Esfandiari; Mahboubeh Irani; Sheyda Ahmadi Koulaei; Narguess Yassa
Journal:  Antimicrob Agents Chemother       Date:  2021-08-17       Impact factor: 5.191
  9 in total

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