| Literature DB >> 10702680 |
K Lehnert1, J Ni, E Leung, S Gough, C M Morris, D Liu, S X Wang, R Langley, G W Krissansen.
Abstract
Herein we report the cloning of cDNAs and incompletely processed hnRNAs from endothelia and heart that encode the alpha10 subunit forming part of the novel collagen type II-binding integrin alpha10beta1 of chondrocytes. Analysis of hnRNA clones and reported expressed sequence tags revealed the positions of 17 putative intron-exon splice junctions shared with those of the p150,95 (ITGAX) gene. Human alpha10 transcripts of 5.4 and 1.8 kb were not restricted to chondrocytes but, instead, were widely expressed in a panel of 24 tissue types, where the highest expression was found in muscle and heart. The human alpha10 subunit gene (ITGA10) was localized to band q21 of chromosome 1. Copyright 2000 S. Karger AG, BaselEntities:
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Year: 1999 PMID： 10702680 DOI： 10.1159/000015434
Source DB: PubMed Journal: Cytogenet Cell Genet ISSN： 0301-0171