H Kaube1, Z Katsarava, T Käufer, H Diener, J Ellrich. 1. Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. holgerk@ion.ucl.ac.uk
Abstract
OBJECTIVE: The medullary R2 response of the blink reflex can be elicited by innocuous and noxious stimuli. The purpose of this study was to elicit a nociception specific R2 response with a new surface electrode. METHODS: In 10 healthy subjects the blink reflex was elicited using a standard (10-15 mA) and a new concentric surface electrode type (0.6-1.6 mA) which produces a pin-prick-like pain. RESULTS: After topical local anaesthesia with lignocaine/prilocaine R1 was unchanged, R2 was attenuated by 12% after standard stimulation but was almost abolished (-91%) with the new electrode type. CONCLUSION: Stimulation with low stimulus intensities but electrode-dependent high current density allows preferential depolarization of superficial nociceptive A-delta fibres. This new method is less traumatic than others and is useful in the study of trigeminal nociception.
OBJECTIVE: The medullary R2 response of the blink reflex can be elicited by innocuous and noxious stimuli. The purpose of this study was to elicit a nociception specific R2 response with a new surface electrode. METHODS: In 10 healthy subjects the blink reflex was elicited using a standard (10-15 mA) and a new concentric surface electrode type (0.6-1.6 mA) which produces a pin-prick-like pain. RESULTS: After topical local anaesthesia with lignocaine/prilocaine R1 was unchanged, R2 was attenuated by 12% after standard stimulation but was almost abolished (-91%) with the new electrode type. CONCLUSION: Stimulation with low stimulus intensities but electrode-dependent high current density allows preferential depolarization of superficial nociceptive A-delta fibres. This new method is less traumatic than others and is useful in the study of trigeminal nociception.
Authors: Eva-Maria Seidel; Daniela M Pfabigan; Andreas Hahn; Ronald Sladky; Arvina Grahl; Katharina Paul; Christoph Kraus; Martin Küblböck; Georg S Kranz; Allan Hummer; Rupert Lanzenberger; Christian Windischberger; Claus Lamm Journal: Hum Brain Mapp Date: 2014-10-16 Impact factor: 5.038
Authors: Marcel Franz; Moritz M Nickel; Alexander Ritter; Wolfgang H R Miltner; Thomas Weiss Journal: J Neurophysiol Date: 2015-02-11 Impact factor: 2.714