Literature DB >> 10699306

Monitoring pharmacokinetics of anticancer drugs: non-invasive investigation using magnetic resonance spectroscopy.

J R Griffiths1, J D Glickson.   

Abstract

Magnetic resonance spectroscopy (MRS) offers the unique advantage of detecting, identifying and quantifying chemicals deep within the living body in a totally non-invasive manner. In studies on pharmacology and toxicology of anticancer drugs, MRS and the closely related technique magnetic resonance imaging (MRI) have many uses. MRS in particular, despite its low sensitivity, offers unique insights into pharmacokinetics (the changing concentration of the drug at its site of action) which can be monitored, and metabolism (both activation and detoxification) can be detected in real time. This review considers some recent work on (19)F, (31)P, (1)H and (13)C MRS of anticancer drugs. Future possibilities for (13)C MRS and (1)H MRS studies of drugs and their metabolites are considered in detail.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10699306     DOI： 10.1016/s0169-409x(99)00057-5

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  12 in total

1.  Albumin-based nanoparticles as magnetic resonance contrast agents: II. Physicochemical characterisation of purified and standardised nanoparticles.

Authors:  A A Abdelmoez; G C Thurner; E A Wallnöfer; N Klammsteiner; C Kremser; H Talasz; M Mrakovcic; E Fröhlich; W Jaschke; P Debbage
Journal:  Histochem Cell Biol       Date:  2010-07-14       Impact factor: 4.304

Review 2.  Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution.

Authors:  Martin Brunner; Oliver Langer
Journal:  AAPS J       Date:  2006-04-14       Impact factor: 4.009

Review 3.  Mass balance studies, with a focus on anticancer drugs.

Authors:  Jan H Beumer; Jos H Beijnen; Jan H M Schellens
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

Review 4.  Quantification in magnetic resonance spectroscopy based on semi-parametric approaches.

Authors:  Danielle Graveron-Demilly
Journal:  MAGMA       Date:  2013-07-28       Impact factor: 2.310

Review 5.  Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer.

Authors:  Kristine Glunde; Dmitri Artemov; Marie-France Penet; Michael A Jacobs; Zaver M Bhujwalla
Journal:  Chem Rev       Date:  2010-05-12       Impact factor: 60.622

Review 6.  Metabolic tumor imaging using magnetic resonance spectroscopy.

Authors:  Kristine Glunde; Zaver M Bhujwalla
Journal:  Semin Oncol       Date:  2011-02       Impact factor: 4.929

7.  Noninvasive visualization of in vivo drug delivery of poly(L-glutamic acid) using contrast-enhanced MRI.

Authors:  Furong Ye; Tianyi Ke; Eun-Kee Jeong; Xuli Wang; Yongen Sun; Melody Johnson; Zheng-Rong Lu
Journal:  Mol Pharm       Date:  2006 Sep-Oct       Impact factor: 4.939

Review 8.  Pharmacokinetic imaging: a noninvasive method for determining drug distribution and action.

Authors:  Alan J Fischman; Nathaniel M Alpert; Robert H Rubin
Journal:  Clin Pharmacokinet       Date:  2002       Impact factor: 6.447

9.  Two-point Dixon technique provides robust fat suppression for multi-mouse imaging.

Authors:  Dustin K Ragan; James A Bankson
Journal:  J Magn Reson Imaging       Date:  2010-02       Impact factor: 4.813

Review 10.  Imaging biochemistry: applications to breast cancer.

Authors:  S M Ronen; M O Leach
Journal:  Breast Cancer Res       Date:  2000-11-24       Impact factor: 6.466
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.