| Literature DB >> 10698457 |
P Belmont1, M Demeunynck, J F Constant, J Lhomme.
Abstract
A new heterodimer adenine-chain-acridine containing a mixed amido-guanidinium linker chain was synthesized. To achieve the synthesis a new method of introduction of aminoalkyl chain at position 9 of adenine was designed. The heterodimer interacts specifically with the abasic sites in DNA and inhibits the major base excision repair enzyme in Escherichia coli, Exonuclease III.Entities:
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Year: 2000 PMID： 10698457 DOI： 10.1016/s0960-894x(99)00681-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823