Literature DB >> 10698449

Synthesis and evaluation of daunorubicin-paclitaxel dimers.

A K Kar1, P D Braun, T J Wandless.   

Abstract

Bifunctional, heterodimeric compounds were synthesized to test their ability to create polyvalent arrays between DNA and microtubules in cells. Each dimer was examined for the capacity to bind to microtubules and for cytotoxicity against MES-SA and MES-SA/Dx5 cell lines.

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Year:  2000        PMID: 10698449     DOI: 10.1016/s0960-894x(99)00667-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

1.  Synthesis and Biological Evaluation of a Biotinylated Paclitaxel With an Extra-Long Chain Spacer Arm.

Authors:  Lev G Lis; Mary A Smart; Anna Luchniak; Mohan L Gupta; Vadim J Gurvich
Journal:  ACS Med Chem Lett       Date:  2012-07-30       Impact factor: 4.345

2.  Molecular-docking-guided design, palladium-catalyzed synthesis and anticancer activity of paclitaxel-benzoxazoles hybrids.

Authors:  Ting Jiang; Ya-Nan Cao; Jin-Bu Xu; Feng Gao; Ling-Li Zheng
Journal:  Sci Rep       Date:  2022-06-15       Impact factor: 4.996

3.  Taccalonolide C-6 Analogues, Including Paclitaxel Hybrids, Demonstrate Improved Microtubule Polymerizing Activities.

Authors:  April L Risinger; Shayne D Hastings; Lin Du
Journal:  J Nat Prod       Date:  2021-06-10       Impact factor: 4.803

  3 in total

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